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Advanced filters: Author: Sriram Srikant Clear advanced filters

Direct activation of a bacterial innate immune system by a viral capsid protein

Genetic, biochemical and structural studies provide insights into the function of Escherichia coli CapRel^SJ46 as a fused anti-phage toxin–antitoxin system that binds SECΦ27 Gp57 capsid protein.

Tong Zhang
Hedvig Tamman
Michael T. Laub
ResearchOpen Access16 Nov 2022
Nature

Volume: 612, P: 132-140
The DarTG toxin-antitoxin system provides phage defence by ADP-ribosylating viral DNA

The DarTG toxin-antitoxin system protects bacteria against phage infection via ADP-ribosylation of the viral DNA, and this can be evaded by phages via mutation of their DNA polymerase or the gp61.2 anti-DarT factor.

Michele LeRoux
Sriram Srikant
Michael T. Laub
Research20 Jun 2022
Nature Microbiology

Volume: 7, P: 1028-1040
Mechanics and pharmacology of substrate selection and transport by eukaryotic ABC exporters

This review proposes an up-to-date, consensus thermodynamic model for the conformational changes associated with transport by the eukaryotic type I exporters from the ABC family and discusses structural insights into ABC transporter pharmacology.

Sriram Srikant
Rachelle Gaudet
Reviews26 Aug 2019
Nature Structural & Molecular Biology

Volume: 26, P: 792-801