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Showing 1–2 of 2 results
Advanced filters: Author: Stéphane Lezmi Clear advanced filters

  • Fluoroquinolone antibiotics are widely used to treat serious bacterial infections, but resistance is an increasing problem. Here the authors describe the synthesis and characterization of novel deoxynybomycin derivatives that exhibit activity against fluoroquinolone-resistant infections in an in vivomodel.

    • Elizabeth I. Parkinson
    • Joseph S. Bair
    • Paul J. Hergenrother
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-9

  • Metabolic labeling of the cell surface with a caged azide sugar enabled cleavage-mediated activation by enzymes overexpressed in cancer cells, allowing enhanced targeted delivery of a doxorubicin conjugate through copper-free click chemistry.

    • Hua Wang
    • Ruibo Wang
    • Jianjun Cheng
    Research
    Nature Chemical Biology
    Volume: 13, P: 415-424