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Showing 1–2 of 2 results
Advanced filters: Author: Stéphane Lolignier Clear advanced filters

  • Nav1.7 channels are known to regulate pain perception in humans and mice. Here, the authors provide evidence that Nav1.7 deletion leads to transcriptional upregulation of opioid peptides in sensory neurons, and that treatment with the opioid blocker naloxone helps reverse analgesia in mice and human Nav1.7 nulls.

    • Michael S. Minett
    • Vanessa Pereira
    • John N. Wood
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-8

  • Opioid analgesic drugs act at opioid receptors to exert analgesic effects, but they also exert adverse side effects. In this study, the authors show that the TREK-1 potassium channel is responsible for mediating the analgesic effects of morphine but not the adverse side effects.

    • Maïly Devilliers
    • Jérôme Busserolles
    • Alain Eschalier
    Research
    Nature Communications
    Volume: 4, P: 1-9