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Showing 1–15 of 15 results
Advanced filters: Author: Staci Sorensen Clear advanced filters

  • Combined patch clamp recording, biocytin staining and single-cell RNA-sequencing of human neurocortical neurons shows an expansion of glutamatergic neuron types relative to mouse that characterizes the greater complexity of the human neocortex.

    • Jim Berg
    • Staci A. Sorensen
    • Ed S. Lein
    ResearchOpen Access
    Nature
    Volume: 598, P: 151-158

  • The affected cellular populations during Alzheimer’s disease progression remain understudied. Here the authors use a cohort of 84 donors, quantitative neuropathology and multimodal datasets from the BRAIN Initiative. Their pseudoprogression analysis revealed two disease phases.

    • Mariano I. Gabitto
    • Kyle J. Travaglini
    • Ed S. Lein
    ResearchOpen Access
    Nature Neuroscience
    Volume: 27, P: 2366-2383

  • Using mouse lines in which subsets of neurons are genetically labelled, the authors provide generalized anatomical rules for connections within and between the cortex and thalamus.

    • Julie A. Harris
    • Stefan Mihalas
    • Hongkui Zeng
    Research
    Nature
    Volume: 575, P: 195-202

  • Sparse labelling and whole-brain imaging are used to reconstruct and classify brain-wide complete morphologies of 1,741 individual neurons in the mouse brain, revealing a dependence on both brain region and transcriptomic profile.

    • Hanchuan Peng
    • Peng Xie
    • Hongkui Zeng
    ResearchOpen Access
    Nature
    Volume: 598, P: 174-181

  • An examination of motor cortex in humans, marmosets and mice reveals a generally conserved cellular makeup that is likely to extend to many mammalian species, but also differences in gene expression, DNA methylation and chromatin state that lead to species-dependent specializations.

    • Trygve E. Bakken
    • Nikolas L. Jorstad
    • Ed S. Lein
    ResearchOpen Access
    Nature
    Volume: 598, P: 111-119

  • Neocortical circuits exhibit diverse cell types that can be difficult to build into computational models. Here the authors employ a genetic algorithm-based parameter optimization to generate multi-compartment Hodgkin-Huxley models for diverse cell types in the Allen Cell Types Database.

    • Nathan W. Gouwens
    • Jim Berg
    • Anton Arkhipov
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13

  • In mouse, an axonal connectivity map showing the wiring patterns across the entire brain has been created using an EGFP-expressing adeno-associated virus tracing technique, providing the first such whole-brain map for a vertebrate species.

    • Seung Wook Oh
    • Julie A. Harris
    • Hongkui Zeng
    Research
    Nature
    Volume: 508, P: 207-214

  • This paper discusses how experimental and computational studies integrating multimodal data, such as RNA expression, connectivity and neural activity, are advancing our understanding of the architecture, mechanisms and function of cortical circuits.

    • Anton Arkhipov
    • Nuno da Costa
    • Hongkui Zeng
    Reviews
    Nature Neuroscience
    Volume: 28, P: 717-730

  • The BRAIN Initiative Cell Census Network has constructed a multimodal cell census and atlas of the mammalian primary motor cortex in a landmark effort towards understanding brain cell-type diversity, neural circuit organization and brain function.

    • Edward M. Callaway
    • Hong-Wei Dong
    • Susan Sunkin
    ResearchOpen Access
    Nature
    Volume: 598, P: 86-102

  • Mammalian cortex comprises a variety of cells, but the extent of this cellular diversity is unknown. The authors defined cell types in the primary visual cortex of adult mice using single-cell transcriptomics. This revealed 49 cell types, including 23 GABAergic, 19 glutamatergic and 7 non-neuronal types.

    • Bosiljka Tasic
    • Vilas Menon
    • Hongkui Zeng
    Research
    Nature Neuroscience
    Volume: 19, P: 335-346