Functional micellar nanocarriers for codelivery of doxorubicin (DOX) and caffeic acid phenethyl ester (CAPE) were successfully developed via coassembly of PEO113-b-PCL35-b-PEO113 and PAA13-b-PCL35-b-PAA13. CAPE was entrapped into the PCL core via hydrophobic interactions, while DOX was loaded in the middle layer through complexation between the amino and carboxylic groups of DOX and PAA. The dual drug-loaded micelles exhibited superior colloidal stability and sustained drug release profiles. The dual drug -loaded system suppressed the proliferation of mouse T-lymphoma L5178Y MDR1 cells more effectively than the single drug-loaded micelles, suggesting a synergistic effect.
- Katya Kamenova
- Georgy Grancharov
- Petar D. Petrov
