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The ESCRT protein CHMP5 promotes T cell leukemia by enabling BRD4-p300-dependent transcription

Cytosolic CHMP5 is known for its primary function in membrane remodelling. Here the authors report that nuclear CHMP5 promotes T cell acute lymphoblastic leukemia initiation and maintenance in part through regulating epigenetic and transcriptional events.

Katharine Umphred-Wilson
Shashikala Ratnayake
Stanley Adoro
ResearchOpen Access03 May 2025
Nature Communications

Volume: 16, P: 1-19
IRE1α–XBP1 safeguards hematopoietic stem and progenitor cells by restricting pro-leukemogenic gene programs

Adoro and colleagues report the involvement of the IRE1α–XBP1 signaling axis in protecting hematopoietic stem and progenitor cells from proteomic stress and as a safeguard against leukemic transformation.

Brendan M. Barton
Francheska Son
Stanley Adoro
Research09 Jan 2025
Nature Immunology

Volume: 26, P: 200-214
IL-21 induces antiviral microRNA-29 in CD4 T cells to limit HIV-1 infection

HIV-infected patients who maintain undetectable virus levels possess elevated plasma concentrations of IL-21. Here, Adoroet al. show that IL-21 inhibits early viral infection in humanized mice and suppresses HIV-1 replication in vitroby upregulating a microRNA via the regulatory protein STAT3.

Stanley Adoro
Juan R. Cubillos-Ruiz
Laurie H. Glimcher
ResearchOpen Access25 Jun 2015
Nature Communications

Volume: 6, P: 1-12
PERK is a critical metabolic hub for immunosuppressive function in macrophages

Raines et al. examine the role of the PERK-mediated ER stress response in promoting and sustaining M2-like macrophages in type 2 immune response and in tumor immunity.

Lydia N. Raines
Haoxin Zhao
Stanley Ching-Cheng Huang
Research28 Feb 2022
Nature Immunology

Volume: 23, P: 431-445
Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

Whether CD8-lineage specification and CD8⁺ T cell differentiation is dependent on intrathymic cytokines signaling is unclear. Singer and co-workers show that interleukin 7 specifies CD8-lineage choice and promotes the differentiation of cytotoxic-lineage T cells.

Jung-Hyun Park
Stanley Adoro
Alfred Singer
Research31 Jan 2010
Nature Immunology

Volume: 11, P: 257-264
Post-translational control of T cell development by the ESCRT protein CHMP5

Thymocytes must undergo positive selection to survive and emigrate to the periphery as mature T cells. Glimcher and colleagues identify CHMP5 as a TCR-sensitive regulator of positive selection that acts by preventing oxidation and degradation of the pro-survival protein Bcl-2.

Stanley Adoro
Kwang Hwan Park
Laurie H Glimcher
Research29 May 2017
Nature Immunology

Volume: 18, P: 780-790
A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells

Transcription factor Foxp3 is essential for the development and function of regulatory T cells, but it does not act in isolation. Benoist and colleagues identify a quintet of factors that facilitate transcriptional regulation by Foxp3.

Wenxian Fu
Ayla Ergun
Christophe Benoist
Research09 Sept 2012
Nature Immunology

Volume: 13, P: 972-980
The transcription factor XBP1 is selectively required for eosinophil differentiation

The transcription factor XBP1 is associated with endoplasmic reticulum stress. Glimcher and colleagues show that XBP1 is expressed during eosinophil differentiation and is uniquely required for the production of granule proteins and eosinophil survival.

Sarah E Bettigole
Raphael Lis
Laurie H Glimcher
Research06 Jul 2015
Nature Immunology

Volume: 16, P: 829-837
'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR

Jung-Hyun Park
Stanley Adoro
Alfred Singer
Research16 Sept 2007
Nature Immunology

Volume: 8, P: 1049-1059
Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice

What determines whether a developing thymocyte becomes a CD4⁺ or CD8⁺T cell has been an issue of longstanding debate. Here, the authors review the models that have been proposed to explain CD4/CD8-lineage choice and update us on the environmental and transcription factors that might mediate this decision.

Alfred Singer
Stanley Adoro
Jung-Hyun Park
Reviews01 Oct 2008
Nature Reviews Immunology

Volume: 8, P: 788-801
Protein quality control through endoplasmic reticulum-associated degradation maintains haematopoietic stem cell identity and niche interactions

Xu, Liu, Pen, Zhang et al. demonstrate that the SEL1L–HRD1 complex, which is part of the ERAD protein quality control machinery, safeguards haematopoietic stem cell identity and niche location by ensuring the haematopoietic stem cell surface expression of MPL.

Longyong Xu
Xia Liu
Xi Chen
Research21 Sept 2020
Nature Cell Biology

Volume: 22, P: 1162-1169
XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway

This study finds that triple-negative breast cancers (TNBC) show an increased basal level of endoplasmic reticulum stress and activation of the XBP1 branch of the unfolded protein response; furthermore, XBP1 promotes tumour formation of TNBC cell lines by interacting with and regulating HIF1α.

Xi Chen
Dimitrios Iliopoulos
Laurie H. Glimcher
Research23 Mar 2014
Nature

Volume: 508, P: 103-107

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