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Showing 1–2 of 2 results
Advanced filters: Author: Stanley van Herk Clear advanced filters

  • Chromosome rearrangements can be a cause of altered oncogene expression in cancer, such as a 3q26 translocation in some acute myeloid leukemias (AML) that leads to overexpression of EVI1. Here the authors engineer this rearrangement in a cell line and show that EVI1 overexpression is a result of ‘enhancer hijacking’ of the MYC superenhancer, which is facilitated by CTCF-mediated loops.

    • Sophie Ottema
    • Roger Mulet-Lazaro
    • Ruud Delwel
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • Leukemias with ambiguous lineage require further characterisation. Here, the authors perform epigenomic and transcriptomic analysis of a subgroup of such leukemias with CpG Island Methylator Phenotype and propose that epigenetic dysregulation and not genetic lesions explains their mixed phenotype.

    • Roger Mulet-Lazaro
    • Stanley van Herk
    • Claudia Gebhard
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-22