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Showing 1–5 of 5 results
Advanced filters: Author: Stavroula Mili Clear advanced filters

  • Subcellular mRNA localization is prevalent but with poorly understood physiological roles. Here, the authors show that Net1 mRNA targeting to the basement membrane controls epithelial tissue organization and keratinocyte-stromal connections.

    • Devon E. Mason
    • Thomas D. Madsen
    • Stavroula Mili
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • Adenomatous polyposis coli (APC) regulates the localization of some mRNAs at cellular protrusions but the underlying mechanisms and functional roles are not known. Here the authors show that APC-dependent RNAs are enriched in contractile protrusions, via detyrosinated microtubules, and enhance cell migration.

    • Tianhong Wang
    • Susan Hamilla
    • Stavroula Mili
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-16

  • Translation of localized mRNAs is an important mechanism for controlling spatially discrete cellular processes. The polarity protein Par-3 is locally translated in axons in response to factors such as NGF and netrin-1, and this increased expression is necessary for factor-stimulated axonal outgrowth.

    • Ian G. Macara
    • Hidekazu Iioka
    • Stavroula Mili
    News & Views
    Nature Cell Biology
    Volume: 11, P: 919-921

  • RNA localization is important in diverse biological process including establishment of polarity. This study has focused on migrating fibroblasts that polarize to form a leading edge and tail, in a process that involves assymetric distribution of RNAs. On a genome-wide scale RNAs that are localized to cell protrusions are identified. Through their 3' UTRs, these transcripts are anchored in granules concentrated at the plus end of microtubules and associate with the APC tumour suppressor.

    • Stavroula Mili
    • Konstadinos Moissoglu
    • Ian G. Macara
    Research
    Nature
    Volume: 453, P: 115-119