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Showing 1–7 of 7 results
Advanced filters: Author: Stefan Eimer Clear advanced filters

  • Methods are reported for the combination of fluorescence nanoscopy using either stimulated emission depletion microscopy (STED) or photoactivated localization microscopy (PALM) with electron microscopy, to achieve correlative imaging in which the super-resolved fluorescence signal is placed in the context of cellular ultrastructure.

    • Shigeki Watanabe
    • Annedore Punge
    • Erik M Jorgensen
    Research
    Nature Methods
    Volume: 8, P: 80-84

  • Amphiphilic proteins act as building blocks for the de novo formation of membrane-based organelles within Escherichia coli. The organelles can be selectively functionalized in vivo with unnatural amino acids and hence may permit chemical reactions inside the cell that have not been possible so far.

    • Matthias C. Huber
    • Andreas Schreiber
    • Stefan M. Schiller
    Research
    Nature Materials
    Volume: 14, P: 125-132

  • The Drosophila proteins Neuroligin (Nlg1) and Neurexin (Nrx-1) form a trans-synaptic complex that regulates synapse formation at the neuromuscular junction. Here the authors show that Syd-1, also known to regulate active zone formation, interacts with presynaptic Nrx-1, promoting synaptic clustering and immobilization of Nrx-1, and subsequent glutamate receptor incorporation.

    • David Owald
    • Omid Khorramshahi
    • Stephan J Sigrist
    Research
    Nature Neuroscience
    Volume: 15, P: 1219-1226

  • TFG-1 is identified as a regulator of COPII coat assembly that interacts with SEC-16 to control protein exit from the endoplasmic reticulum. TFG–kinase fusion proteins have been detected in some cancers and might promote oncogenesis by prematurely phosphorylating target substrates as they exit the endoplasmic reticulum.

    • Kristen Witte
    • Amber L. Schuh
    • Anjon Audhya
    Research
    Nature Cell Biology
    Volume: 13, P: 550-558

  • In the cochlea, ribbon synapses are used to transmit acoustic information from inner hair cells to spiral ganglion cells. Here the authors find that the properties of these synapses vary along the tonotopic axis, providing a candidate presynaptic mechanism for modulating the dynamics of ganglion cell spiking.

    • Alexander C Meyer
    • Thomas Frank
    • Tobias Moser
    Research
    Nature Neuroscience
    Volume: 12, P: 444-453