Theralin, which simultaneously fixes and decalcifies bone tissue, was compared with formalin fixation with acid decalcification in primary bone cancer cases. Use of theralin improved (a) sample processing time, (b) tissue histomorphology, (c) protein and DNA extractability, and (d) enabled standard FISH staining in bone. This unlocks the molecular archive within bone for the standard tissue analysis pipeline.
- Claudius Mueller
- Marco Gambarotti
- Virginia Espina