Nature Search

Neural xenografts contribute to long-term recovery in stroke via molecular graft-host crosstalk

In this study, Weber et al., investigate the long-term survival and integration of human stem cell-derived neural progenitors into the stroke-injured mouse brains. They report grafted cells integrate into host circuits and mediate repair through graft-host crosstalk via neurexin, neuregulin, neural cell adhesion molecules, and SLIT signalling pathways.

Rebecca Z. Weber
Beatriz Achón Buil
Ruslan Rust
ResearchOpen Access16 Sept 2025
Nature Communications

Volume: 16, P: 1-23
Disruption of ClC-3-mediated 2Cl⁻/H⁺ exchange leads to behavioural deficits and thalamic atrophy

Carina Balduin
Guanxiao Qi
Antje Willuweit
ResearchOpen Access29 Sept 2025
Scientific Reports

Volume: 15, P: 1-18
Identification of gene regulatory networks affected across drug-resistant epilepsies

Epilepsy is a chronic, heterogeneous disease with an urgent need for novel therapies. Here, the authors show a systematic comparison of the global molecular signature of refractory epilepsies elucidating the key mechanisms of the disease pathology.

Liesbeth François
Alessia Romagnolo
Eleonora Aronica
ResearchOpen Access11 Mar 2024
Nature Communications

Volume: 15, P: 1-17
Crym-positive striatal astrocytes gate perseverative behaviour

In mice, a population of astrocytes in the central striatum, characterized by expression of μ-crystallin, has a role in perseveration phenotypes that are often associated with human neuropsychiatric disorders.

Matthias Ollivier
Joselyn S. Soto
Baljit S. Khakh
ResearchOpen Access28 Feb 2024
Nature

Volume: 627, P: 358-366
Astrocyte–neuron subproteomes and obsessive–compulsive disorder mechanisms

Analyses of the proteomes of astrocytes and neurons in a cell-specific and subcompartment-specific manner reveal distinct roles for these cell types that are relevant to obsessive–compulsive disorder and perhaps other brain disorders.

Joselyn S. Soto
Yasaman Jami-Alahmadi
Baljit S. Khakh
ResearchOpen Access12 Apr 2023
Nature

Volume: 616, P: 764-773
Regulatory T cells in the mouse hypothalamus control immune activation and ameliorate metabolic impairments in high-calorie environments

Hypothalamus participates in systemic metabolic processes, while high calorie intake increases immune activation in the central nervous system. Here the authors show that reduced regulatory T cells in the hypothalamus contribute to elevated immune activation in a high calorie environment, thereby prompting a potential therapy target for metabolic diseases.

Maike Becker
Stefanie Kälin
Carolin Daniel
ResearchOpen Access20 Mar 2025
Nature Communications

Volume: 16, P: 1-23
Somatic mutation landscapes at single-molecule resolution

NanoSeq is used to detect mutations in single DNA molecules and analyses show that mutational processes that are independent of cell division are important contributors to somatic mutagenesis.

Federico Abascal
Luke M. R. Harvey
Iñigo Martincorena
Research28 Apr 2021
Nature

Volume: 593, P: 405-410
A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation

In this study, the authors generate a new mouse model that allows selective genetic targeting of microglial cells. Using this model, they show that elimination of TGF-β-activated kinase 1 (TAK1) specifically in microglial cells reduces pathology in a mouse model of multiple sclerosis by inhibiting NF-κB, ERK and JNK signaling pathways.

Tobias Goldmann
Peter Wieghofer
Marco Prinz
Research29 Sept 2013
Nature Neuroscience

Volume: 16, P: 1618-1626
Nuclear export inhibitors avert progression in preclinical models of inflammatory demyelination

In this study, the authors report the molecular characterization of orally bioavailable and blood-brain-barrier permeable inhibitors of the nuclear export molecule Xpo1/CRM1 and define the immunomodulatory and neuroprotective effects in preclinical models of inflammatory demyelination and excitatory neurotoxicity.

Jeffery D Haines
Olivier Herbin
Patrizia Casaccia
Research23 Feb 2015
Nature Neuroscience

Volume: 18, P: 511-520
Variants in SART3 cause a spliceosomopathy characterised by failure of testis development and neuronal defects

The SART3 gene encodes an RNA-binding protein critical for spliceosome function. Here, the authors find that bi-allelic variants in SART3 underlie a congenital condition characterised by neuro-developmental defects and 46,XY gonadal dysgenesis.

Katie L. Ayers
Stefanie Eggers
Andrew H. Sinclair
ResearchOpen Access09 Jun 2023
Nature Communications

Volume: 14, P: 1-21
The centrosome protein AKNA regulates neurogenesis via microtubule organization

The interphase centrosome protein AKNA is necessary and sufficient for the organization of centrosomal microtubules, mediates delamination in the formation of the subventricular zone and regulates exit from this zone.

Germán Camargo Ortega
Sven Falk
Magdalena Götz
Research20 Feb 2019
Nature

Volume: 567, P: 113-117
Functional metagenomic screening identifies an unexpected β-glucuronidase

Functional screening of a large metagenomic library with a droplet microfluidics platform enabled the discovery of SN243, a bacterial β-glucuronidase from the glycoside hydrolase 3 family, which was characterized structurally and biochemically.

Stefanie Neun
Paul Brear
Florian Hollfelder
Research07 Jul 2022
Nature Chemical Biology

Volume: 18, P: 1096-1103
The stem cell potential of glia: lessons from reactive gliosis

In the adult brain, neurogenesis occurs in a few restricted niches. However, the activation of glia following brain injury can endow these cells with stem cell properties. Götz and colleagues discuss how a more detailed knowledge of reactive gliosis might enable the stem cell potential of glia to be harnessed.

Stefanie Robel
Benedikt Berninger
Magdalena Götz
Reviews20 Jan 2011
Nature Reviews Neuroscience

Volume: 12, P: 88-104
Fos After Single and Repeated Self-Administration of Cocaine and Saline in the Rat: Emphasis on the Basal Forebrain and Recalibration of Expression

Daniel S Zahm
Mary L Becker
Michela Marinelli
Research30 Sept 2009
Neuropsychopharmacology

Volume: 35, P: 445-463
Induced neural progenitor cells and iPS-neurons from major depressive disorder patients show altered bioenergetics and electrophysiological properties

Julian Triebelhorn
Iseline Cardon
Christian H. Wetzel
ResearchOpen Access22 Jun 2022
Molecular Psychiatry

Volume: 29, P: 1217-1227
Identification of adeno-associated virus variants for gene transfer into human neural cell types by parallel capsid screening

Lea Jessica Flitsch
Kathleen Börner
Oliver Brüstle
ResearchOpen Access19 May 2022
Scientific Reports

Volume: 12, P: 1-12
Shank2/3 double knockout-based screening of cortical subregions links the retrosplenial area to the loss of social memory in autism spectrum disorders

Débora Garrido
Stefania Beretta
Tobias M. Boeckers
ResearchOpen Access13 Sept 2022
Molecular Psychiatry

Volume: 27, P: 4994-5006
The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell–derived leukocyte elastase

Inhibition of T cell–derived leukocyte elastase by neuronal SerpinA3N or the drug Sivelestat reduces neuropathic pain.

Lucas Vicuña
David E Strochlic
Rohini Kuner
Research27 Apr 2015
Nature Medicine

Volume: 21, P: 518-523
A CRHR1 antagonist prevents synaptic loss and memory deficits in a trauma-induced delirium-like syndrome

Silvia Cursano
Chiara R. Battaglia
Tobias M. Boeckers
ResearchOpen Access12 Feb 2020
Molecular Psychiatry

Volume: 26, P: 3778-3794

Search

Neural xenografts contribute to long-term recovery in stroke via molecular graft-host crosstalk

Disruption of ClC-3-mediated 2Cl⁻/H⁺ exchange leads to behavioural deficits and thalamic atrophy

Identification of gene regulatory networks affected across drug-resistant epilepsies

Crym-positive striatal astrocytes gate perseverative behaviour

Astrocyte–neuron subproteomes and obsessive–compulsive disorder mechanisms

Regulatory T cells in the mouse hypothalamus control immune activation and ameliorate metabolic impairments in high-calorie environments

Somatic mutation landscapes at single-molecule resolution

A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation

Nuclear export inhibitors avert progression in preclinical models of inflammatory demyelination

Variants in SART3 cause a spliceosomopathy characterised by failure of testis development and neuronal defects

The centrosome protein AKNA regulates neurogenesis via microtubule organization

Functional metagenomic screening identifies an unexpected β-glucuronidase

The stem cell potential of glia: lessons from reactive gliosis

Fos After Single and Repeated Self-Administration of Cocaine and Saline in the Rat: Emphasis on the Basal Forebrain and Recalibration of Expression

Induced neural progenitor cells and iPS-neurons from major depressive disorder patients show altered bioenergetics and electrophysiological properties

Identification of adeno-associated virus variants for gene transfer into human neural cell types by parallel capsid screening

Shank2/3 double knockout-based screening of cortical subregions links the retrosplenial area to the loss of social memory in autism spectrum disorders

The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell–derived leukocyte elastase

A CRHR1 antagonist prevents synaptic loss and memory deficits in a trauma-induced delirium-like syndrome

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