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Showing 1–3 of 3 results
Advanced filters: Author: Stefanie Redemann Clear advanced filters
  • A connection between centrosomes and chromosomes is a key feature of mitotic spindles. Here the authors generate 3D reconstructions of whole mitotic spindles in earlyC. elegansembryos and show that chromosomes are anchored by the entire spindle network and that connections through kinetochore microtubules are few and likely very transient.

    • Stefanie Redemann
    • Johannes Baumgart
    • Thomas Müller-Reichert
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-13
  • Changing the codon sequence in Caenorhabditis elegans genes allows fine-tuning of transgene expression from high to low expression. The same strategy is likely applicable for Drosophila melanogaster and Saccharomyces cerevisiae.

    • Stefanie Redemann
    • Siegfried Schloissnig
    • Henrik Bringmann
    Research
    Nature Methods
    Volume: 8, P: 250-252
  • IFNγ-inducible guanylate binding proteins (GBPs) recognize the Toxoplasma gondii vacuole during infection. Here, the authors report that inducible nitric oxide synthase (iNOS) is necessary for efficient parasite clearance by GBPs and that reactive nitrogen species produced by iNOS lead to nitration of the parasite vacuole and collapse of the intravacuolar network space, preventing parasite escape from GBP targeting.

    • Xiao-Yu Zhao
    • Samantha L. Lempke
    • Sarah E. Ewald
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16