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Showing 1–2 of 2 results
Advanced filters: Author: Stefano Cacchione Clear advanced filters

  • Telomerase protects chromosome ends in stem cells and cancer cells. Here the authors show that Trimethylguaonsine Synthase 1 (TGS-1) – dependent trimethylguanosine capping of the RNA component of the human telomerase complex has an important role in directing telomere dependent telomere maintenance and suppressing the ALT pathway in cancer cells.

    • Valentina Buemi
    • Odessa Schillaci
    • Stefan Schoeftner
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • Drosophila telomeres are elongated by transposition of specialized retroelements rather than telomerase activity. Here, the authors show that Separase is enriched at Drosophila telomeres and loss of Sse, the gene encoding Separase, leads to telomere defects, suggesting a role for Separase in telomere protection.

    • Francesca Cipressa
    • Patrizia Morciano
    • Giovanni Cenci
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-9