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Advanced filters: Author: Stefano Dini Modigliani Clear advanced filters

  • Abnormal accumulation of the RNA-binding protein FUS and mutations within the FUS gene have been found in association with amyotrophic lateral sclerosis (ALS). Here, Dini Modigliani et al.uncover a FUS regulatory circuit that implicates the microRNAs miR-141 and miR-200a in a feedback loop disrupted by an ALS-associated mutation.

    • Stefano Dini Modigliani
    • Mariangela Morlando
    • Irene Bozzoni
    Research
    Nature Communications
    Volume: 5, P: 1-7

  • The RNA binding protein FUS functions in several RNA biosynthetic processes and has been linked to the pathogenesis of amyotrophic lateral sclerosis (ALS). Here the authors show that FUS controls back-splicing reactions leading to circular RNA (circRNA) production in stem cell-derived motor neurons and that ALS-associated FUS mutations affect the biogenesis of circRNAs.

    • Lorenzo Errichelli
    • Stefano Dini Modigliani
    • Irene Bozzoni
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-11