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Showing 1–4 of 4 results
Advanced filters: Author: Stefano M Pagnotta Clear advanced filters

  • Oncogenic FGFR3–TACC3 gene fusions signal through phosphorylated PIN4 to trigger biogenesis of peroxisomes and synthesis of new proteins, enabling mitochondrial respiration and tumour growth.

    • Véronique Frattini
    • Stefano M. Pagnotta
    • Antonio Iavarone
    Research
    Nature
    Volume: 553, P: 222-227

  • Gelareh Zadeh, Kenneth Aldape and colleagues present an integrative genomic analysis of schwannomas. In addition to finding recurrent mutations in ARID1A, ARID1B and DDR1, they identify a recurrent SH3PXD2A-HTRA1 fusion that confers increased proliferation, invasion and in vivo transformation, and is associated with sensitivity to MEK inhibition.

    • Sameer Agnihotri
    • Shahrzad Jalali
    • Gelareh Zadeh
    Research
    Nature Genetics
    Volume: 48, P: 1339-1348

  • Chordoid glioma is a slow growing diencephalic tumor whose mutational landscape is poorly characterized. Here, the authors perform whole-exome and RNA-sequencing and find that 15 of 16 chordoid glioma cases studied harbor the same PRKCA mutation which results in enhanced proliferation.

    • Shai Rosenberg
    • Iva Simeonova
    • Marc Sanson
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-9