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Showing 1–5 of 5 results
Advanced filters: Author: Steffen Rump Clear advanced filters

  • One-carbon substrates are attractive feedstocks for circular bioeconomy. Here, the authors design an erythrulose monophosphate (EuMP) cycle for formaldehyde assimilation, demonstrate the activity of the core reactions in E. coli, and show its integration with pathway reactions existed in pentose phosphate pathway and glycolysis.

    • Tong Wu
    • Paul A. Gómez-Coronado
    • Hai He
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-12

  • The future of bioproduction lies in efficient C1 utilization. Methanol derived from CO2 can be fed to engineered bacteria that convert it into platform chemicals currently produced from fossil fuels. Now, recent results confirm we are getting closer.

    • Jan Lukas Krüsemann
    • Steffen N. Lindner
    News & Views
    Nature Catalysis
    Volume: 7, P: 472-474

  • miR-132 was shown to drive pathological cardiac remodeling, a hallmark of heart failure. Here, the authors show that an antisense inhibitor of miR-132 has favourable pharmacokinetics, safety-tolerability and preclinical efficacy in mouse and porcine models of heart failure.

    • Ariana Foinquinos
    • Sandor Batkai
    • Thomas Thum
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10

  • AGO2 binds to miRNAs to repress expression of cognate target mRNAs. Here the authors report that heterozygous AGO2 mutations result in defects in neurological development and impair RNA interference.

    • Davor Lessel
    • Daniela M. Zeitler
    • Hans-Jürgen Kreienkamp
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14