A genome-wide association study involving lung cancer finds that genetic sequences in the nicotinic acetylcholine receptor subunit gene cluster contribute to susceptibility. This paper finds that alleles present in a cluster of nicotinic acid receptor genes affect smoking quantity in European samples, and are therefore also associated with risk of lung cancer and peripheral arterial disease.
- Thorgeir E. Thorgeirsson
- Frank Geller
- Kari Stefansson
