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Showing 1–4 of 4 results
Advanced filters: Author: Stepan Denisov Clear advanced filters

  • Resistance mutations are challenging to characterize because their effects are highly context dependent. Here, authors present a quantitative mutant screening technique that deconstructs how factors like antibiotic mechanism and genetic background interact to govern resistance evolution.

    • Matthew J. Jago
    • Jake K. Soley
    • Mato Lagator
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13

  • Ticks inject evasins at the bite site to bind multiple redundant chemokines and inhibit inflammation allowing blood feeding. Here, the authors identify evasin derived short peptides with broad spectrum anti-chemokine activity that could be used to develop new treatments for inflammatory disease.

    • Serena Vales
    • Jhanna Kryukova
    • Shoumo Bhattacharya
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17

  • The pro-tumorigenic effects of vimentin have been attributed to intracellular functions in tumour cells so far. Here, the authors show that tumour endothelial cells can secrete vimentin as a pro-angiogenic factor and that targeting of vimentin can be used as an immunotherapeutic strategy.

    • Judy R. van Beijnum
    • Elisabeth J. M. Huijbers
    • Arjan W. Griffioen
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-20

  • Functional RNA secondary structure is important for the pre-mRNA processing including splicing, cleavage and polyadenylation, and RNA editing. Here the authors present a catalog of conserved long-range RNA structures in the human transcriptome by defining pairs of conserved complementary regions (PCCR) in pre-aligned evolutionarily conserved regions.

    • Svetlana Kalmykova
    • Marina Kalinina
    • Dmitri Pervouchine
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17