Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–5 of 5 results
Advanced filters: Author: Stephan Emmrich Clear advanced filters

  • While micro-RNAs are known regulators of haematopoiesis and leukemogenesis, the role of long non-coding RNAs is less clear. Here the authors provide a non-coding RNA expression landscape of the human hematopoietic system, highlighting their role in the formation and maintenance of the human blood hierarchy.

    • Adrian Schwarzer
    • Stephan Emmrich
    • Jan-Henning Klusmann
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-17

  • Naked mole rat (NMR) is an exceptionally long-lived rodent species that on the phenotypic level seems to evade aging. Here the authors show that NMRs age epigenetically, while epigenetic clocks detect that NMR queens age more slowly than nonbreeding females.

    • Steve Horvath
    • Amin Haghani
    • Vera Gorbunova
    ResearchOpen Access
    Nature Aging
    Volume: 2, P: 46-59

  • Mice overexpressing Has2 from the naked mole-rat showed an increase in hyaluronan levels in several tissues, and a lower incidence of spontaneous and induced cancer, attenuated inflammation through several pathways, extended lifespan and improved healthspan.

    • Zhihui Zhang
    • Xiao Tian
    • Vera Gorbunova
    Research
    Nature
    Volume: 621, P: 196-205

  • Naked mole-rats are long-lived rodents known to be resistant to the development of cancer, yet their immune system remains poorly explored. Here, the authors identify natural killer-like effector γδ T cells that express a dominant γδ T cell receptor and may serve a role in tumour immunosurveillance.

    • Guillem Sanchez Sanchez
    • Stephan Emmrich
    • David Vermijlen
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • Concomitant overexpression of microRNAs miR-100 and miR-125b-1 within the host long non-coding RNA MIR100HG induces cetuximab resistance in cancer in the absence of previously associated genetic alterations. miR-100 and miR-125b target negative regulators of Wnt/β-catenin signaling and sustain drug resistance through feedback inhibition of GATA6 expression and this resistance can be overcome by pharmacological inhibition of Wnt activity. These findings, together with those by Tan et al. in the previous issue, highlight the emerging functional role of non-coding RNAs in modulating the response to anti-cancer therapies.

    • Yuanyuan Lu
    • Xiaodi Zhao
    • Robert J Coffey
    Research
    Nature Medicine
    Volume: 23, P: 1331-1341