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Showing 1–3 of 3 results

Advanced filters: Author: Stephan Wolpert Clear advanced filters

A phase I/IIa safety and efficacy trial of intratympanic gamma-secretase inhibitor as a regenerative drug treatment for sensorineural hearing loss

Pharmacological inhibition of gamma-secretase induced partial recovery of hearing in animal models. Here, the authors present the safety and efficacy results and key learnings of the First in Human Phase I/IIa study of a gamma-secretase inhibitor in patients with acquired Hearing Loss.

Anne G. M. Schilder
Stephan Wolpert
Athanasios G. Bibas
ResearchOpen Access01 Mar 2024
Nature Communications

Volume: 15, P: 1-9
cGMP-Prkg1 signaling and Pde5 inhibition shelter cochlear hair cells and hearing function

Noise-induced hearing loss (NIHL) is a prevalent problem in the industrialized world. Now, Lukas Rüttiger and colleagues show that the phosphodiesterase inhibitor vardenafil can prevent NIHL in rats and mice.

Mirko Jaumann
Juliane Dettling
Lukas Rüttiger
Research22 Jan 2012
Nature Medicine

Volume: 18, P: 252-259
Phonation differentiation by non-contact laryngeal magnetomyography

Justus Marquetand
Nima Noury
Stephan Wolpert
ResearchOpen Access29 May 2025
Scientific Reports

Volume: 15, P: 1-9

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