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Showing 1–11 of 11 results
Advanced filters: Author: Stephan von Haehling Clear advanced filters

  • Muscle wasting (sarcopenia) and loss of weight (cachexia) can occur in patients with heart failure. In this Review, von Haehling and colleagues provide an overview of the prevalence and pathophysiological mechanisms of these processes in heart failure, and discuss potential therapeutic strategies, including exercise training, nutritional supplements, and drug treatments.

    • Stephan von Haehling
    • Nicole Ebner
    • Stefan D. Anker
    Reviews
    Nature Reviews Cardiology
    Volume: 14, P: 323-341

  • In this Review, von Haehling and colleagues provide clinicians with practical recommendations for patients with heart failure who plan to travel, including guidelines for pre-travel risk assessment and special considerations for patients who have undergone recent surgery or have a cardiac implantable electronic device.

    • Stephan von Haehling
    • Christoph Birner
    • Gerd Hasenfuss
    Reviews
    Nature Reviews Cardiology
    Volume: 19, P: 302-313

  • Iron deficiency is very common worldwide, and has detrimental effects in individuals with cardiovascular disease. Correction of iron deficiency via intravenous iron supplementation results in symptomatic improvement in patients with heart failure, and improved exercise capacity in patients with pulmonary hypertension, but iron administration after cardiac transplantation surgery is contraindicated.

    • Stephan von Haehling
    • Ewa A. Jankowska
    • Stefan D. Anker
    Reviews
    Nature Reviews Cardiology
    Volume: 12, P: 659-669

  • There is no agreed definition for cachexia, and this hampers research and treatment. This Viewpoint emphasizes the importance of definitive cut-off limits for weight loss over time, and the need for straightforward diagnostic criteria. The authors suggest cut-off values for cardiac cachexia but acknowledge that the values might differ in other conditions.

    • Jochen Springer
    • Stephan von Haehling
    • Stefan D Anker
    Reviews
    Nature Clinical Practice Endocrinology & Metabolism
    Volume: 2, P: 416-417

  • In a multicenter, randomized trial, patients with heart failure with preserved ejection fraction who underwent a regimen of combined endurance and resistance exercise training over the course of 1 year did not show a statistically significant improvement in the modified Packer score—the primary efficacy endpoint—as compared to patients who received usual care, but they did show improvements in secondary endpoints for maximal oxygen consumption and NYHA heart failure class.

    • Frank Edelmann
    • Rolf Wachter
    • Martin Halle
    ResearchOpen Access
    Nature Medicine
    Volume: 31, P: 306-314

  • Cachexia is associated with poor prognosis in heart failure. Here the authors show that mice and patients with cardiac cachexia display reduced skeletal muscle expression and circulating levels of Musclin. Musclin ablation in skeletal muscle worsens, while its muscle-specific overexpression ameliorates heart failure in mice.

    • Malgorzata Szaroszyk
    • Badder Kattih
    • Joerg Heineke
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17

  • Heart failure and kidney disease share a number of pathophysiological pathways. Here, Stefan Anker and colleagues discuss crosstalk between the heart and the kidneys, the epidemiology of heart failure and kidney dysfunction, and the treatment of cardio-renal syndromes.

    • Joerg C. Schefold
    • Gerasimos Filippatos
    • Stephan von Haehling
    Reviews
    Nature Reviews Nephrology
    Volume: 12, P: 610-623