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Showing 1–4 of 4 results
Advanced filters: Author: Stephanie A. Schalbetter Clear advanced filters

  • Schalbetter et al. show by Hi-C and modelling that mitotic chromosome compaction in budding yeast occurs by cis-looping of chromatin, and reveal distinct roles for cohesin and condensin depending on chromatin context.

    • Stephanie Andrea Schalbetter
    • Anton Goloborodko
    • Jonathan Baxter
    Research
    Nature Cell Biology
    Volume: 19, P: 1071-1080

  • During meiotic prophase chromosomes organise into a series of chromatin loops, but the mechanisms of assembly remain unclear. Here the authors use Saccharomyces cerevisiae to elucidate how this elaborate three-dimensional chromosome organisation is linked to genomic sequence, and demonstrate an essential role for cohesin during this process.

    • Stephanie A. Schalbetter
    • Geoffrey Fudenberg
    • Matthew J. Neale
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • A new mechanism of chromosomal rearrangement is identified through the observation that broken or collapsed DNA replication forks restarted by homologous recombination have a high propensity for U-turns at short inverted repeats; the error-prone nature of this mechanism is suggested to contribute to gross chromosomal rearrangements and copy-number variations present in cancer and other genomic disorders.

    • Ken’Ichi Mizuno
    • Izumi Miyabe
    • Johanne M. Murray
    Research
    Nature
    Volume: 493, P: 246-249

  • The three-dimensional structure of pericentromeres in budding yeast is defined by convergent genes, which mark pericentromere borders and trap cohesin complexes loaded at centromeres, generating an architecture that allows correct chromosome segregation.

    • Flora Paldi
    • Bonnie Alver
    • Adele L. Marston
    Research
    Nature
    Volume: 582, P: 119-123