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Structure-guided unlocking of Na_X reveals a non-selective tetrodotoxin-sensitive cation channel

Na_X is an atypical member of the voltage-gated sodium channel family that may contribute to Na⁺ homeostasis. Here, the authors describe the structural and functional attributes of the human Na_X channel to reveal new insights into its physiology.

Cameron L. Noland
Han Chow Chua
Jian Payandeh
ResearchOpen Access17 Mar 2022
Nature Communications

Volume: 13, P: 1-10

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Structure-guided unlocking of NaX reveals a non-selective tetrodotoxin-sensitive cation channel

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Structure-guided unlocking of Na_X reveals a non-selective tetrodotoxin-sensitive cation channel