In human embryonic stem cells, the histone demethylase LSD1 is found to occupy the promoters of a subset of developmental genes that bear methylation marks on the lysine residues 4 and 27 of histone 3, and are co-occupied by OCT4 and NANOG. LSD1 participates in the silencing of these genes by controlling the levels of methylation at their regulatory regions on lysine 4 of histone 3.
- Antonio Adamo
- Borja Sesé
- Juan Carlos Izpisua Belmonte