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Showing 1–4 of 4 results
Advanced filters: Author: Stephanie Dobersch Clear advanced filters

  • Basal Pancreatic Ductal Adenocarcinoma (PDAC) is more aggressive than the classical subtype of pancreatic cancer. Here the authors report that RNA-binding protein LIN28B and its target HMGA2 drive basal PDAC pathogenesis by reducing PP2A methylation and activity, resulting in enhanced protein synthesis and aggressive features.

    • Stephanie Dobersch
    • Naomi Yamamoto
    • Sita Kugel
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17

  • The order of DNA methylation and histone modifications during transcription remained unclear. Here the authors show that HMGA2 induces DNA nicks at TGFB1-responsive genes, promoting nucleosome incorporation containing γ-H2AX, which is required for repair-mediated DNA demethylation and transcription.

    • Stephanie Dobersch
    • Karla Rubio
    • Guillermo Barreto
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-20

  • Idiopathic pulmonary fibrosis (IPF) is a lethal disease with insufficient treatment strategies. Here the authors show that reduction of the microRNA MIRLET7D and hyperactivation of EP300 contribute to impaired epigenetic silencing by the MiCEE complex in pulmonary fibroblasts of IPF patients, and demonstrate the benefit of inhibiting EP300 for the treatment of IPF.

    • Karla Rubio
    • Indrabahadur Singh
    • Guillermo Barreto
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-16