The authors propose a framework for drug repositioning by comparing GWAS-imputed transcriptomes with drug-induced gene expression profiles. The approach was applied to seven psychiatric disorders. Repositioning candidates were significantly enriched for known psychiatric medications or for therapies considered in clinical trials, supporting a role of GWAS in guiding drug discovery.
- Hon-Cheong So
- Carlos Kwan-Long Chau
- Pak-Chung Sham
