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Showing 1–6 of 6 results
Advanced filters: Author: Stephanie Marciniak Clear advanced filters

  • Red imported fire ants were accidently introduced to North America in the 1930s, since then imposing novel selective pressures on native ecosystems. This study identifies genomic signatures of recent adaptation in native eastern fence lizards potentially linked to exposure to these ants.

    • Braulio A. Assis
    • Alexis P. Sullivan
    • George H. Perry
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12

  • FXR regulates the levels of ACE2 in tissues of the respiratory and gastrointestinal systems that are affected by COVID-19, and inhibiting FXR with ursodeoxycholic acid downregulates ACE2 and reduces susceptibility to SARS-CoV-2 infection.

    • Teresa Brevini
    • Mailis Maes
    • Fotios Sampaziotis
    ResearchOpen Access
    Nature
    Volume: 615, P: 134-142

  • Ancient genomes can inform our understanding of the history of human adaptation through the direct tracking of changes in genetic variant frequency across different geographical locations and time periods. The authors review recent ancient DNA analyses of human, archaic hominin, pathogen, and domesticated animal and plant genomes, as well as the insights gained regarding past human evolution and behaviour.

    • Stephanie Marciniak
    • George H. Perry
    Reviews
    Nature Reviews Genetics
    Volume: 18, P: 659-674

  • Molecular, pharmacological and functional data show that haematopoietic stem cells (HSCs) are predisposed to ER-stress-mediated apoptosis compared to closely related progenitors; a framework for understanding how stress signalling is coordinated within the hematopoietic hierarchy and integrated with stemness is provided, and may have implications for the improvement of clinical transplantation of HSCs.

    • Peter van Galen
    • Antonija Kreso
    • John E. Dick
    Research
    Nature
    Volume: 510, P: 268-272