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Showing 1–3 of 3 results
Advanced filters: Author: Stephen A Shinsky Clear advanced filters

  • Polyamines bind to nucleic acids and their function is regulated by reversible acetylation. Here, the authors show that histone deacetylase 10 is a polyamine deacetylase and present its crystal structure with a bound polyamine transition state analogue inhibitor.

    • Yang Hai
    • Stephen A. Shinsky
    • David W. Christianson
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-9

  • Crotonylated lysine residues within histones are linked to transcriptional activation in a process involving histone mark ‘reader’ proteins. Crystallographic analysis of the YEATS domain of the Taf14 protein reveals a mode of crotonylated histone mark recognition via a π-sandwich motif.

    • Forest H Andrews
    • Stephen A Shinsky
    • Tatiana G Kutateladze
    Research
    Nature Chemical Biology
    Volume: 12, P: 396-398

  • Terpene cyclases catalyze the formation of diverse hydrocarbon scaffolds found in terpenoids. Here, the authors report the cryptic function of class I terpene cyclases as aromatic prenyltransferases and the universality of this cryptic feature is confirmed using enzymes from different sources.

    • Haibing He
    • Guangkai Bian
    • Tiangang Liu
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13