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Showing 1–2 of 2 results
Advanced filters: Author: Stephen A. Caponetti Clear advanced filters

  • The broad activity windows of current base editors pose a major challenge to their therapeutic application. Here, the authors established a generalizable re-engineering framework to narrow the activity windows of diverse base editors, streamlining the development of therapeutic base editing.

    • Izabella Valdez
    • Ian O’Connor
    • Tingting Jiang
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • Profiling of a case of secondary T cell lymphoma following anti-CD19 CAR T cell therapy suggests that it was not caused by CAR insertional mutagenesis, with single-center analysis indicating that secondary T cell lymphoma risk after commercial CAR T cell treatment is low.

    • Guido Ghilardi
    • Joseph A. Fraietta
    • Marco Ruella
    Research
    Nature Medicine
    Volume: 30, P: 984-989