Until recently, the active form of vitamin D was thought to function primarily as a regulator of calcium and phosphate metabolism; discovery of the vitamin D receptor in tissues not involved in calcium and phosphate homeostasis has challenged this view. The authors of this Review discuss the immunomodulatory role of vitamin D and evidence for its involvement in the pathogenesis of inflammatory bowel disease.
- Wee-Chian Lim
- Stephen B Hanauer
- Yan Chun Li