Nature Search

Failure to detect DNA-guided genome editing using Natronobacterium gregoryi Argonaute

Seung Hwan Lee
Giandomenico Turchiano
Jin-Soo Kim
Correspondence28 Nov 2016
Nature Biotechnology

Volume: 35, P: 17-18
In vivo genome editing using a high-efficiency TALEN system

Although zebrafish is an important animal model for basic vertebrate biology and human disease modelling, rapid targeted genome modification has not been possible in this species; here a technique based on improved artificial transcription activator-like effector nucleases (TALENs) allows precise sequence modifications at pre-determined genomic locations.

Victoria M. Bedell
Ying Wang
Stephen C. Ekker
Research23 Sept 2012
Nature

Volume: 491, P: 114-118
The product of hedgehog autoproteolytic cleavage active in local and long-range signalling

Jeffery A. Porter
Doris P. von Kessler
Philip A. Beachy
Research23 Mar 1995
Nature

Volume: 374, P: 363-366
Twisted gastrulation is a conserved extracellular BMP antagonist

Jeffrey J. Ross
Osamu Shimmi
J. Lawrence Marsh
Research22 Mar 2001
Nature

Volume: 410, P: 479-483
Mutations in the human Sonic Hedgehog gene cause holoprosencephaly

Erich Roessler
Elena Belloni
Maximilian Muenke
Research01 Nov 1996
Nature Genetics

Volume: 14, P: 357-360
Students being and becoming scientists: measured success in a novel science education partnership

Joanna Yang
Thomas J LaBounty
Chris Pierret
ResearchOpen Access01 Mar 2016
Palgrave Communications

Volume: 2, P: 1-9
A method for lifelong genetic manipulation of regenerating hepatocytes in mouse

Kirk J Wangensteen
Andrew Wilber
Stephen C Ekker
Research04 Aug 2008
Cell Research

Volume: 18, P: S31
Author Correction: The LipoGlo reporter system for sensitive and specific monitoring of atherogenic lipoproteins

James H. Thierer
Stephen C. Ekker
Steven A. Farber
Amendments and CorrectionsOpen Access21 Jul 2020
Nature Communications

Volume: 11, P: 1
In vivo protein trapping produces a functional expression codex of the vertebrate proteome

A protein-trap mutagenesis system efficiently disrupts expression and reports endogenous expression patterns of genes in the zebrafish. The authors used it to generate an initial collection of 350 freely available fish lines.

Karl J Clark
Darius Balciunas
Stephen C Ekker
Research08 May 2011
Nature Methods

Volume: 8, P: 506-512
Effective targeted gene ‘knockdown’ in zebrafish

Aidas Nasevicius
Stephen C. Ekker
Research01 Oct 2000
Nature Genetics

Volume: 26, P: 216-220
The LipoGlo reporter system for sensitive and specific monitoring of atherogenic lipoproteins

Atherosclerosis results from the accumulation of lipoproteins in the vascular wall. Here, Thierer et al. report the design of a chemiluminescent reporter for atherogenic lipoproteins using fusion of apolipoprotein-B to a luciferase enzyme, and find it bears potential for the identification of regulators of lipoprotein metabolism in vivo.

James H. Thierer
Stephen C. Ekker
Steven A. Farber
ResearchOpen Access31 Jul 2019
Nature Communications

Volume: 10, P: 1-14
Precision gene editing technology and applications in nephrology

The application of precision gene editing has great potential to accelerate basic research and advance clinical practice in nephrology. Here, the authors discuss this technology and the challenges and potential of genome editing in the kidney.

Zachary WareJoncas
Jarryd M. Campbell
Stephen C. Ekker
Reviews08 Aug 2018
Nature Reviews Nephrology

Volume: 14, P: 663-677
The NIH Somatic Cell Genome Editing program

This Perspective discusses how the Somatic Cell Genome Editing Consortium aims to accelerate the implementation of safe and effective genome-editing therapies in the clinic.

Krishanu Saha
Erik J. Sontheimer
Jiangbing Zhou
ReviewsOpen Access07 Apr 2021
Nature

Volume: 592, P: 195-204
Multifunctional role of the transcription factor Blimp-1 in coordinating plasma cell differentiation

Blimp-1 is known to act as a transcriptional repressor by suppressing genes associated with mature and activated germinal center B cells. Busslinger and colleagues show that Blimp-1 can also directly activate gene expression in plasma cells, including those encoding proteins that regulate the production of membrane-bound immunoglobulin versus secreted immunoglobulin.

Martina Minnich
Hiromi Tagoh
Meinrad Busslinger
Research18 Jan 2016
Nature Immunology

Volume: 17, P: 331-343
Wnt5a Is Required for Cardiac Outflow Tract Septation in Mice

J Robert Schleiffarth
Anthony D Person
Anna Petryk
Research01 Apr 2007
Pediatric Research

Volume: 61, P: 386-391
Zebrafishology, study design guidelines for rigorous and reproducible data using zebrafish

A review emphasizes the advantages of using zebrafish in research, outlines key differences in experimental approaches, and offers guidelines for designing studies in a way that enhances experimental rigor and reproducibility.

Victoria M. Bedell
Priya Dubey
Stephen C. Ekker
ReviewsOpen Access13 May 2025
Communications Biology

Volume: 8, P: 1-14
Endogenous zebrafish proneural Cre drivers generated by CRISPR/Cas9 short homology directed targeted integration

Maira P. Almeida
Jordan M. Welker
Maura McGrail
ResearchOpen Access18 Jan 2021
Scientific Reports

Volume: 11, P: 1-12

Search

Failure to detect DNA-guided genome editing using Natronobacterium gregoryi Argonaute

In vivo genome editing using a high-efficiency TALEN system

The product of hedgehog autoproteolytic cleavage active in local and long-range signalling

Twisted gastrulation is a conserved extracellular BMP antagonist

Mutations in the human Sonic Hedgehog gene cause holoprosencephaly

Students being and becoming scientists: measured success in a novel science education partnership

A method for lifelong genetic manipulation of regenerating hepatocytes in mouse

Author Correction: The LipoGlo reporter system for sensitive and specific monitoring of atherogenic lipoproteins

In vivo protein trapping produces a functional expression codex of the vertebrate proteome

Effective targeted gene ‘knockdown’ in zebrafish

The LipoGlo reporter system for sensitive and specific monitoring of atherogenic lipoproteins

Precision gene editing technology and applications in nephrology

The NIH Somatic Cell Genome Editing program

Multifunctional role of the transcription factor Blimp-1 in coordinating plasma cell differentiation

Wnt5a Is Required for Cardiac Outflow Tract Septation in Mice

Zebrafishology, study design guidelines for rigorous and reproducible data using zebrafish

Endogenous zebrafish proneural Cre drivers generated by CRISPR/Cas9 short homology directed targeted integration

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