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Showing 1–24 of 24 results
Advanced filters: Author: Stephen E. Girardin Clear advanced filters

  • T helper type 17 (TH17) responses are crucial for immunity to intestinal pathogens. Here, Stephen E. Girardin, Dana J. Philpott and their colleagues report that early production of IL-17A by enteric CD4+ T helper cells is important for host defense against Citrobacter and Salmonella infection. Induction of IL-17A is dependent on Nod-like receptors. suggesting early, innate TH17 responses are involved in controlling enteric pathogens and may have a role in inflammatory bowel disease.

    • Kaoru Geddes
    • Stephen J Rubino
    • Stephen E Girardin
    Research
    Nature Medicine
    Volume: 17, P: 837-844

  • Recent studies have revealed a role for host translation inhibition in the innate immune surveillance and detection of bacterial pathogens. Lemaitre and Girardin review these findings and discuss whether translation inhibition is a direct innate immune signal or rather part of a more general metabolic stress response to infection.

    • Bruno Lemaitre
    • Stephen E. Girardin
    Reviews
    Nature Reviews Microbiology
    Volume: 11, P: 365-369

  • Microbes in the gut can influence distant events, affecting the function of neutrophils in the circulation of mice (pages 228–231). The findings should lead to new studies examining how intestinal microbes affect immunity.

    • Dana J Philpott
    • Stephen E Girardin
    News & Views
    Nature Medicine
    Volume: 16, P: 160-161

  • Data from a variety of sources—including satellite, climate and soil data, as well as field-collected information on plant traits—are pooled and analysed to map the functional diversity of tropical forest canopies globally.

    • Jesús Aguirre-Gutiérrez
    • Sami W. Rifai
    • Yadvinder Malhi
    ResearchOpen Access
    Nature
    Volume: 641, P: 129-136

  • The record-breaking 2023 wildfire season in Canada ( ~ 15 Mha burned) was enabled by early snowmelt, drought, and extreme weather. It had profound impacts that included evacuation of >200 communities, millions exposed to hazardous smoke, and a strain on fire-fighting resources.

    • Piyush Jain
    • Quinn E. Barber
    • Marc-André Parisien
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14

  • A dataset of 16 plant traits sampled from 2,461 individual trees from 74 tropical forest sites around the world is used to show a strong link between climate and plant functional diversity and redundancy, with drier tropical forests likely being less able to respond to declines in water availability.

    • Jesús Aguirre‐Gutiérrez
    • Erika Berenguer
    • Yadvinder Malhi
    Research
    Nature Ecology & Evolution
    Volume: 6, P: 878-889

  • Nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs) are a family of intracellular sensors that have key roles in innate immunity and inflammation. This Review discusses the effect that research on NLRs will have on vaccination, treatment of chronic inflammatory disorders and acute bacterial infections.

    • Kaoru Geddes
    • João G. Magalhães
    • Stephen E. Girardin
    Reviews
    Nature Reviews Drug Discovery
    Volume: 8, P: 465-479

  • The 3020insC mutation in Nod2 is associated with Crohn's disease, but how it influences disease pathogenesis is unknown. A new study shows that the 3020insC mutant protein fails to activate a key transcription factor that drives interleukin 10 expression, resulting in reduced production of this anti-inflammatory cytokine.

    • Dana J Philpott
    • Stephen E Girardin
    News & Views
    Nature Immunology
    Volume: 10, P: 455-457

  • Nucleotide oligomerization domain-containing protein 1 (NOD1) and NOD2 are pattern-recognition receptors that detect bacterial peptidoglycan. Signalling through NODs initiates a variety of effector immune responses that seem to be crucial for maintaining immune homeostasis with the host microbiota. Indeed, mutations in NOD1 and NOD2 are associated with both intestinal and extra-intestinal disease. This Review summarizes our current understanding of the NODs.

    • Dana J. Philpott
    • Matthew T. Sorbara
    • Stephen E. Girardin
    Reviews
    Nature Reviews Immunology
    Volume: 14, P: 9-23

  • IgA secreting plasma cells in the lamina propria are shown to be an important source of iNOS and TNF required to maintain the homeostatic balance between intestinal microbes and the immune system.

    • Jörg H. Fritz
    • Olga Lucia Rojas
    • Jennifer L. Gommerman
    Research
    Nature
    Volume: 481, P: 199-203

  • Rich evidence of the potential co-benefits and trade-offs of natural climate solutions is available but remains poorly understood. Assessing the literature with machine learning methods, this study maps and analyses the growing evidence of trade-offs in natural climate solutions globally.

    • Charlotte H. Chang
    • James T. Erbaugh
    • Yuta J. Masuda
    Research
    Nature Sustainability
    Volume: 8, P: 75-85

  • Metabolic stress is shown to impair IKKβ function, which leads to the activation of pro-caspase-8 downstream of TLR4 engagement. Caspase-8 cleaves and activates the NLRP1B inflammasome, thereby enhancing a cell death signal.

    • Justin J. Meade
    • Sarah Stuart
    • Jeremy Mogridge
    ResearchOpen Access
    Communications Biology
    Volume: 7, P: 1-16