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Showing 1–3 of 3 results
Advanced filters: Author: Stephen Lenzini Clear advanced filters

  • Acute liver failure arises from rapid cell death and impaired liver regeneration. Here, the authors show that scalable, high-purity engineered extracellular vesicles derived from stem cells promote the clearance of dying hepatocytes and drive liver repair through in vivo macrophage reprogramming.

    • Seohyun Kim
    • Yoon Kyoung Kim
    • In-San Kim
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20

  • Stress relaxation properties of the matrix as well as water transport through aquaporin-1 enable extracellular vesicles to deform and travel through the dense mesh of the extracellular matrix between cells.

    • Stephen Lenzini
    • Raymond Bargi
    • Jae-Won Shin
    Research
    Nature Nanotechnology
    Volume: 15, P: 217-223

  • Extracellular vesicles (EVs) are lipid-bound nanoscale mediators of intercellular communication. This Review discusses EVs in the context of the extracellular matrix, highlighting how the understanding of their interactions inspires materials design to control the release, retention and production of EVs for various biological and therapeutic applications.

    • Koushik Debnath
    • Kevin Las Heras
    • Jae-Won Shin
    Reviews
    Nature Reviews Materials
    Volume: 8, P: 390-402