Nature Search

Changes in susceptibility of Plasmodium falciparum to antimalarial drugs in Uganda over time: 2019–2024

In this study, the authors present antimalarial drug resistance surveillance data from Uganda over the period 2019-2024. They measure ex vivo susceptibility to nine standard antimalarials in 1,114 isolates and characterise sequences of markers of drug susceptibility.

Martin Okitwi
Stephen Orena
Philip J. Rosenthal
ResearchOpen Access09 Aug 2025
Nature Communications

Volume: 16, P: 1-9
Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cecilia Anza-Ramirez
J. Jaime Miranda
Yves Miel H. Zuniga
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-36
Developmental alterations in the frequency map of the mammalian cochlea

Stephen M. Echteler
Ellis Arjmand
Peter Dallos
Research14 Sept 1989
Nature

Volume: 341, P: 147-149
Major sea level fall during the Pliocene M2 glaciation

This study refines benthic foraminiferal Mg/Ca paleothermometry to reduce uncertainties to ±0.2-0.3 °C, which was then applied in Atlantic and Pacific sediment cores to reconstruct Mid-Pliocene M2 glaciation sea-level changes.

Zifei Yang
Caroline H. Lear
Amy Thomas-Sparkes
ResearchOpen Access16 Aug 2025
Nature Communications

Volume: 16, P: 1-12
Joint, multifaceted genomic analysis enables diagnosis of diverse, ultra-rare monogenic presentations

Using well-calibrated statistical methods the authors jointly analyze Undiagnosed Diseases Network genomes, identifying known and novel disease genes. Software is publicly available to support future cross-cohort rare disease discovery efforts.

Shilpa Nadimpalli Kobren
Mikhail A. Moldovan
Shamil R. Sunyaev
ResearchOpen Access07 Aug 2025
Nature Communications

Volume: 16, P: 1-19
Dcc Mediates Functional Assembly of Peripheral Auditory Circuits

Young J. Kim
Sheng-zhi Wang
Li I. Zhang
ResearchOpen Access04 Apr 2016
Scientific Reports

Volume: 6, P: 1-14
Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product

Peter Whyte
Karen J. Buchkovich
Ed Harlow
Research14 Jul 1988
Nature

Volume: 334, P: 124-129
Neurotrophins promote motor neuron survival and are present in embryonic limb bud

Christopher E. Henderson
William Camu
Arnon Rosenthal
Research20 May 1993
Nature

Volume: 363, P: 266-270
Fluorescence detection in automated DNA sequence analysis

Lloyd M. Smith
Jane Z. Sanders
Leroy E. Hood
Research12 Jun 1986
Nature

Volume: 321, P: 674-679
Atypical Forms of Tubercle Bacilli (Strain B.C.G.)

STEPHEN E. JUHASZ
EDITH M. MANKIEWICZ
Research29 Mar 1958
Nature

Volume: 181, P: 929-930
Biogenesis of chemotactic molecules by the arachidonate lipoxygenase system of platelets

STEPHEN R. TURNER
JOHN A. TAINER
WILLIAM S. LYNN
Research23 Oct 1975
Nature

Volume: 257, P: 680-681
BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra

Carolyn Hyman
Magdalena Hofer
Ronald M. Lindsay
Research21 Mar 1991
Nature

Volume: 350, P: 230-232
T-cell colonies recognize antigen in association with specific epitopes on Ia molecules

Robert B. Clark
Joe Chiba
Ethan M. Shevach
Research04 Feb 1982
Nature

Volume: 295, P: 412-414
The 1883 eruption of Krakatau

Stephen Self
Michael R. Rampino
Research24 Dec 1981
Nature

Volume: 294, P: 699-704
Structure and binding properties of Pangolin-CoV spike glycoprotein inform the evolution of SARS-CoV-2

It has been suggested that pangolin coronaviruses may be the origin of SARS-CoV-2. Here the authors show that the Pangolin-CoV spike is structurally closely related to the closed form of SARS-CoV-2 spike and exhibits similar binding properties to human and pangolin ACE2; although neither spike binds bat ACE2.

Antoni G. Wrobel
Donald J. Benton
Steven J. Gamblin
ResearchOpen Access05 Feb 2021
Nature Communications

Volume: 12, P: 1-6
Evolution of the SARS-CoV-2 spike protein in the human host

The SARS-CoV-2 spike has been evolving in the human population. The variants of concern alpha and beta evolved to optimise spike openness and so ability to bind its receptor ACE2, the affinity towards the receptor, and stability upon receptor binding.

Antoni G. Wrobel
Donald J. Benton
Steven J. Gamblin
ResearchOpen Access04 Mar 2022
Nature Communications

Volume: 13, P: 1-7
Antibody-mediated disruption of the SARS-CoV-2 spike glycoprotein

Here, the authors characterise the binding and neutralisation properties of CR3022, a neutralising Ab isolated from a convalescent SARS patient, against SARS-CoV-2 spike trimers and show using Cryo-EM the disruption of SARS-CoV-2 spike by CR3022 Fab.

Antoni G. Wrobel
Donald J. Benton
Steven J. Gamblin
ResearchOpen Access21 Oct 2020
Nature Communications

Volume: 11, P: 1-5
Correlations between T-cell specificity and the structure of the antigen receptor

Pamela J. Fink
Louis A. Matis
Stephen M. Hedrick
Research15 May 1986
Nature

Volume: 321, P: 219-226
The contribution of de novo coding mutations to meningomyelocele

Exome sequencing of 851 trios from more than 2,500 individuals finds 187 genes with de novo mutations that contribute to meningomyelocele (spina bifida) and highlights critical pathways required for neural tube closure.

Yoo-Jin Jiny Ha
Ashna Nisal
Joseph G. Gleeson
Research26 Mar 2025
Nature

Volume: 641, P: 419-426
Human gene expression first occurs between the four- and eight-cell stages of preimplantation development

Peter Braude
Virginia Bolton
Stephen Moore
Research31 Mar 1988
Nature

Volume: 332, P: 459-461
The envelope glycoprotein from tick-borne encephalitis virus at 2 Å resolution

Félix A. Rey
Franz X. Heinz
Stephen C. Harrison
Research25 May 1995
Nature

Volume: 375, P: 291-298
Cofactor requirements of splicing of purified messenger RNA precursors

Stephen F. Hardy
Paula J. Grabowski
Phillip A. Sharp
Research22 Mar 1984
Nature

Volume: 308, P: 375-377
Allele-specific and Mutator-associated instability at the Rpl disease-resistance locus of maize

Jeffrey L. Bennetzen
Min-Min Qin
Albert H. Ellingboe
Research24 Mar 1988
Nature

Volume: 332, P: 369-370
Velocity structure of the ring nebula around supernova 1987A

Arlin P. S. Crotts
Stephen R. Heathcote
Research25 Apr 1991
Nature

Volume: 350, P: 683-685
APC mutations occur early during colorectal tumorigenesis

Steven M. Powell
Nathan Zilz
Kenneth W. Kinzler
Research17 Sept 1992
Nature

Volume: 359, P: 235-237
The lipid bilayer as a ‘solvent’ for small hydrophobic molecules

STEPHEN H. WHITE
Research01 Jul 1976
Nature

Volume: 262, P: 421-422
Disorganised and ‘excessive’ reinnervation of frog cardiac ganglia

CHIEN-PING KO
STEPHEN ROPER
Research01 Jul 1978
Nature

Volume: 274, P: 286-288
Combining Asian and European genome-wide association studies of colorectal cancer improves risk prediction across racial and ethnic populations

Most genetic studies have been done on European cohorts, which affects the efficacy of polygenic risk scores in non-European populations. Here, the authors demonstrate that a colorectal cancer PRS including Asian and European ancestries has improved performance over the European-centric PRS across racial and ethnic groups.

Minta Thomas
Yu-Ru Su
Li Hsu
ResearchOpen Access02 Oct 2023
Nature Communications

Volume: 14, P: 1-13
Adipose tissue and skeletal muscle wasting precede clinical diagnosis of pancreatic cancer

Advanced pancreatic cancer is associated with tissue wasting; however, the timing of tissue loss prior to diagnosis and the potential utility of such loss for earlier pancreatic cancer detection are not well understood. Here the authors show that skeletal muscle loss can be detected on CT imaging 1–2 years before a clinical diagnosis of pancreatic cancer.

Ana Babic
Michael H. Rosenthal
Brian M. Wolpin
ResearchOpen Access18 Jul 2023
Nature Communications

Volume: 14, P: 1-9
The role of cyclic nucleotide mediators in latency and reactivation of HSV-1 infected neuroblastoma cells

Alejandro Rodriguez
Maite Sainz De La Maza
C Stephen Foster
Research01 Sept 1991
Eye

Volume: 5, P: 627-635
Author Correction: Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome

Hua Su
Fei Yang
Michael Karin
Amendments and CorrectionsOpen Access18 Jun 2025
Nature

Volume: 643, P: E10
Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity

The L protein of segmented, negative strand RNA viruses contains the RNA-dependent RNA polymerase essential for virus amplification. Here, the authors report cryoEM structures of the Lassa virus L protein in active, RNA-bound states, and provide mechanistic insights.

Tomas Kouba
Dominik Vogel
Stephen Cusack
ResearchOpen Access02 Dec 2021
Nature Communications

Volume: 12, P: 1-18
CD8⁺ T cell-mediated endotheliopathy is a targetable mechanism of neuro-inflammation in Susac syndrome

Susac syndrome is an inflammatory pathology of the brain endothelium. Here the authors show that the pathology is driven by CD8 T cells attacking the endothelium, and that blocking T cell-endothelial adhesion ameliorates the disease in a mouse model, and associates with improved clinical score in 4 patients.

Catharina C. Gross
Céline Meyer
Roland Liblau
ResearchOpen Access18 Dec 2019
Nature Communications

Volume: 10, P: 1-19
A framework for detecting noncoding rare-variant associations of large-scale whole-genome sequencing studies

STAARpipeline is a comprehensive framework for flexible and scalable rare-variant association analysis using whole-genome sequencing data and annotation information.

Zilin Li
Xihao Li
Xihong Lin
Research27 Oct 2022
Nature Methods

Volume: 19, P: 1599-1611
Benzoxazole-derivatives enhance progranulin expression and reverse the aberrant lysosomal proteome caused by GRN haploinsufficiency

Heterozygous loss-of-function mutations in the GRN gene are a major cause of hereditary frontotemporal dementia, and there is currently no treatment. Here, the authors report and utilize small molecule positive regulators of GRN expression to boost progranulin levels from the remaining functional GRN allele, thus restoring progranulin levels back to normal within the brain.

Rachel Tesla
Charlotte Guhl
Joachim Herz
ResearchOpen Access20 Jul 2024
Nature Communications

Volume: 15, P: 1-20
The development of cataract following trabeculectomy

Michael P Clarke
Stephen A Vernon
James H Sheldrick
Research01 Jul 1990
Eye

Volume: 4, P: 577-583
Body composition and lung cancer-associated cachexia in TRACERx

Results of the TRACERx study shed new light into the association between body composition and body weight with survival in individuals with non-small cell lung cancer, and delineate potential biological processes and mediators contributing to the development of cancer-associated cachexia.

Othman Al-Sawaf
Jakob Weiss
Charles Swanton
Research12 Apr 2023
Nature Medicine

Volume: 29, P: 846-858
Errors in the deposited SFTSV L protein structure

Stephen Cusack
Maria Rosenthal
Research29 Apr 2021
Nature Microbiology

Volume: 6, P: 549-550
Decreased susceptibility of Plasmodium falciparum to both dihydroartemisinin and lumefantrine in northern Uganda

In this work, susceptibilities to two key antimalarials, dihydroartemisinin and lumefantrine, were associated with multiple genetic polymorphisms in Plasmodium falciparum, and were lower in northern Uganda, where resistance-mediating mutations have emerged, compared to eastern Uganda.

Patrick K. Tumwebaze
Melissa D. Conrad
Philip J. Rosenthal
ResearchOpen Access26 Oct 2022
Nature Communications

Volume: 13, P: 1-12
The DNA sequence of the human X chromosome

Mark T. Ross
Darren V. Grafham
David R. Bentley
Research17 Mar 2005
Nature

Volume: 434, P: 325-337
Lung adenocarcinoma promotion by air pollutants

Combination of epidemiology, preclinical models and ultradeep DNA profiling of clinical cohorts unpicks the inflammatory mechanism by which air pollution promotes lung cancer

William Hill
Emilia L. Lim
Charles Swanton
Research05 Apr 2023
Nature

Volume: 616, P: 159-167
Viral-mediated transduction of auditory neurons with opsins for optical and hybrid activation

Rachael T. Richardson
Alex C. Thompson
James B. Fallon
ResearchOpen Access27 May 2021
Scientific Reports

Volume: 11, P: 1-17
Transcript errors generate amyloid-like proteins in human cells

Amyloid-like proteins are central to age-related diseases, such as Alzheimer’s and Parkinson’s. Here, the authors show that transcription errors can produce mutant proteins with enhanced amyloid- and prion-like properties in human cells.

Claire S. Chung
Yi Kou
Marc Vermulst
ResearchOpen Access07 Oct 2024
Nature Communications

Volume: 15, P: 1-17
Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis

Piotr Sicinski
Joana Liu Donaher
Robert A. Weinberg
Research05 Dec 1996
Nature

Volume: 384, P: 470-474
New recombinant HLA-B alleles in a tribe of South American Amerindians indicate rapid evolution of MHC class I loci

David I. Watkins
Stephen N. McAdam
Norman L. Letvin
Research28 May 1992
Nature

Volume: 357, P: 329-333
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

A human–SARS-CoV-2 protein interaction map highlights cellular processes that are hijacked by the virus and that can be targeted by existing drugs, including inhibitors of mRNA translation and predicted regulators of the sigma receptors.

David E. Gordon
Gwendolyn M. Jang
Nevan J. Krogan
Research30 Apr 2020
Nature

Volume: 583, P: 459-468
Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale

STAAR is a powerful rare variant association test that incorporates variant functional categories and complementary functional annotations using a dynamic weighting scheme based on annotation principal components. STAAR accounts for population structure and relatedness and is scalable for analyzing large whole-genome sequencing studies.

Xihao Li
Zilin Li
Xihong Lin
Research24 Aug 2020
Nature Genetics

Volume: 52, P: 969-983
Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion

Cryo-electron microscopy structures of consecutive binding events of ACE2 in complex with the spike protein of SARS-CoV-2 reveal the mechanisms of receptor binding by the spike protein and activation for membrane fusion by the spike protein of SARS-CoV-2.

Donald J. Benton
Antoni G. Wrobel
Steven J. Gamblin
Research17 Sept 2020
Nature

Volume: 588, P: 327-330
NON-INVASIVE RIGHT AND LEFT SYSTOLIC TIME INTERVALS BY ECHOCARDIOGRAPHY

Stephen Hirschfeld
Richard A Meyer
Samuel Kaplan
Research01 Apr 1974
Pediatric Research

Volume: 8, P: 350
Dynamic pigmentary and structural coloration within cephalopod chromatophore organs

Chromatophores in cephalopod skin are known for fast changes in coloration due to light-scattering pigment granules. Here, authors demonstrate structural coloration facilitated by reflectin in sheath cells and offer insights into the interplay between structural and pigmentary coloration elements.

Thomas L. Williams
Stephen L. Senft
Leila F. Deravi
ResearchOpen Access01 Mar 2019
Nature Communications

Volume: 10, P: 1-15

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