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Susac syndrome is an inflammatory pathology of the brain endothelium. Here the authors show that the pathology is driven by CD8 T cells attacking the endothelium, and that blocking T cell-endothelial adhesion ameliorates the disease in a mouse model, and associates with improved clinical score in 4 patients.

Brain circuits exhibit different amounts of plasticity over different developmental stages. Here authors show that there is a transition of the influence of spatiotemporal patterns, from instructive to permissive, around the time of the onset of visual experience.

Post-infectious myalgic encephalomyelitis/chronic fatigue syndrome (PI-ME/CFS) is a disabling disorder, yet the clinical phenotype is poorly defined and the pathophysiology unknown. Here, the authors conduct deep phenotyping of a cohort of PI-ME/CFS patients.

The goals, resources and design of the NHLBI Trans-Omics for Precision Medicine (TOPMed) programme are described, and analyses of rare variants detected in the first 53,831 samples provide insights into mutational processes and recent human evolutionary history.

The influence of X chromosome genetic variation on blood lipids and coronary heart disease (CHD) is not well understood. Here, the authors analyse X chromosome sequencing data across 65,322 multi-ancestry individuals, identifying associations of the Xq23 locus with lipid changes and reduced risk of CHD and diabetes mellitus.

Reduction in key air pollutants, especially particulate carbon, can help mitigate Arctic warming with associated benefits for global climate and human health, according to Earth system model simulations under future emissions scenarios.

Xanthorhodopsins with carotenoid antennas are found to be widespread in cyanobacteria and adapted to extreme polar environments by modulating light-harvesting efficiency under prolonged low light intensities and spectral shifts.

The Tyrolean Iceman is 5,300 years old and his mitochondrial genome has been previously sequenced. This study reports the full genome sequence of the Iceman and reveals that he probably had brown eyes, was at risk for coronary disease and may have been infected with the pathogen Lyme borreliosis.

The behaviour of Antarctic ice sheets during warm climates of the past is poorly understood. Here, the authors combine cosmogenic nuclide exposure ages and numerical simulations in an effort to assess changes in East Antarctic ice sheet thickness since the Pliocene.

Northern Hemisphere photosynthesis is thought to respond positively to temperature variations, yet the strength of this relationship may change over time. Here, using a combination of satellite data and models, the authors assess the temporal change of this relationship over the past three decades.

Analysis of 97,691 high-coverage human blood DNA-derived whole-genome sequences enabled simultaneous identification of germline and somatic mutations that predispose individuals to clonal expansion of haematopoietic stem cells, indicating that both inherited and acquired mutations are linked to age-related cancers and coronary heart disease.

Whole genome sequences enable discovery of rare variants which may help to explain the heritability of common diseases. Here the authors find that ultra-rare variants explain ~50% of coronary artery disease (CAD) heritability and highlight several functional processes including cell type-specific regulatory mechanisms as key drivers of CAD genetic risk.

The dominant driver of variations in global land carbon sink remains unclear. Here the authors show that the seasonal compensation of temperature effects on land carbon sink in the Northern Hemisphere could induce a global water dominance.

Louis Miller (National Institute of Allergy and Infectious Diseases) and Stephen Hoffman (Naval Medical Research Institute) review progress toward developing malaria vaccines. They argue that multiple antigens from different stages may be needed to protect the diverse populations at risk, and that an optimal vaccine would induce immunity against all stages. Vaccines for African children, in whom the major mortality occurs, must induce immunity against asexual blood stages.

Stephen Giovannoni and Ulrich Stingl discuss recent advances in the cultivation of bacterioplankton, and review the new insights into the ecology and physiology of these microorganisms that have been enabled by metagenomic and population studies of cultivated strains.

Through development of non-fullerene acceptors, OPVs have reached efficiencies of 18%, yet the inadequate operational lifetime still poses a challenge for the commercialisation. Here, the authors investigate the origin of instability of NFA solar cells, and propose some strategies to mitigate this issue.

There is much uncertainty on the response of soil microbial communities to warming, particularly in the subsoil. Here, the authors investigate microbial community and metabolism response to 4.5 years of whole-profile soil warming, finding depth-dependent effects and elevated subsoil microbial respiration.

The Getz region of West Antarctica is losing ice at an increasing rate; however, the forcing mechanisms remain unclear. Here we show for the first time that since 1994, widespread speedup has occurred on the majority of glaciers in the Getz drainage basin, with some glaciers speeding up by over 44 %.

Accurate seasonal forecasts of sea ice are highly valuable, particularly in the context of sea ice loss due to global warming. A new machine learning tool for sea ice forecasting offers a substantial increase in accuracy over current physics-based dynamical model predictions.

How climate services support on-farm management is not well understood. Here research shows that multi-decadal projections help farmers better identify future climate risks through reducing complexity and psychological distance, although this may be impeded by lack of confidence in data.

Most studies of the genetics of the metabolome have been done in individuals of European descent. Here, the authors integrate genomics and metabolomics in Black individuals, highlighting the value of whole genome sequencing in diverse populations and linking circulating metabolites to human disease.

Internal low-frequency variability in the Arctic atmosphere can explain about half the summer sea ice decline over the past decades, according to an analysis of large ensembles of fully coupled climate model simulations.

The Southern Ocean is critically important for global climate yet poorly represented by climate models. Here the authors trace sea surface temperature biases in this region to cloud-related errors in atmospheric-model simulated surface heat fluxes and provide a pathway to improve the models.

Surface meltwater is known to influence the dynamics of some glaciers and the Greenland ice sheet. Here, the authors have identified the first examples of the drainage of surface meltwater to the bed of outlet glaciers on the Antarctic Peninsula that trigger large and rapid accelerations of ice flow.

Only about 15% of water cycle diagrams include human interaction with water, although human freshwater appropriation amounts to about half of global river discharge, according to an analysis of 464 water cycle diagrams and a synthesis of the global water cycle.

Projecting the future retreat and thus global sea level contributions of Antarctica’s Pine Island Glacier is hampered by a poor grasp of what controls flow at the ice base. Here, via high-resolution ice-radar imaging, the authors show diverse landscapes beneath the glacier fundamentally influence ice flow.

The Arctic is warming and sea ice is declining, but how the two link is unclear. This study shows changes in summertime atmospheric circulation and internal variability may have caused up to 60% of September sea-ice decline since 1979.

The risk of epidemics originating from wild animals demands close monitoring of emerging infectious disease (EID) events and their predictors. Here, the authors update a global database of EID events, analyze their environmental and biological correlates, and present a new global hotspot map of zoonotic EID risk.

The Last Ice Area could disappear just over a decade after the central Arctic Ocean becomes seasonally ice-free, with significant impacts on ice-dependent species, according to high-resolution simulations from the Community Earth System Model accounting for sea ice export through the Canadian Arctic Archipelago and Nares Strait.

A study using a newly developed framework shows how future peak temperature is related to cumulative emissions of long-lived greenhouse gases such as carbon dioxide and sustained emissions of shorter-lived species such as methane, and suggests an approach for limiting future warming to 2 °C above pre-industrial levels.

Determining stratospheric ozone levels from before instrumental records began has proved difficult. Measurements of the chemical composition of plant spore walls suggest that ultraviolet-B-absorbing compounds have the potential to act as a proxy for past changes in ultraviolet-B radiation and stratospheric ozone.

The last glacial period was characterized by large, rapid climate fluctuations. An analysis of a speleothem from New Mexico shows that the coldest conditions over Greenland coincide with increased winter precipitation in the southwestern United States, which can be attributed to a southward displacement of the polar jet stream and the North American storm track.

The GREGoR consortium provides foundational resources and substrates for the future of rare disease genomics.

A study shows that clonal haematopoiesis of indeterminate potential is associated with an increased risk of chronic liver disease specifically through the promotion of liver inflammation and injury.

This study examines the impact of herbivorous insects on biogeochemical cycling within forests. From a global network of 74 plots within 40 mature, undisturbed broadleaved forests, they show that background levels of insect herbivory are sufficiently large to alter both ecosystem element cycling and influence terrestrial carbon cycling.

Accounting for meltwater from the Antarctic Ice Sheet in simulations of global climate leads to substantial changes in future climate projections and identifies a potential feedback mechanism that exacerbates melting.

For a suitably designed organic multilayer structure, optically or electrically generated electrons confined to a thin fullerene channel can diffuse over surprisingly long distances of several centimetres.

About a third of the sediment delivery of the Mekong River is shown to be associated with rainfall generated by tropical cyclones, suggesting that future delta stability will be strongly moderated by changes to tropical cyclone intensity, frequency and track.

STAAR is a powerful rare variant association test that incorporates variant functional categories and complementary functional annotations using a dynamic weighting scheme based on annotation principal components. STAAR accounts for population structure and relatedness and is scalable for analyzing large whole-genome sequencing studies.

Platelet aggregation is associated with myocardial infarction and stroke. Here, the authors have conducted a whole genome sequencing association study on platelet aggregation, discovering a locus in RGS18, where enhancer assays suggest an effect on activity of haematopoeitic lineage transcription factors.

Pooling participant-level genetic data into a single analysis can result in variance stratification, reducing statistical performance. Here, the authors develop variant-specific inflation factors to assess variance stratification and apply this to pooled individual-level data from whole genome sequencing.

GATA2 regulatory mutations are associated with hereditary congenital facial paresis in humans. A genetically engineered mouse model recapitulates the human phenotype, showing altered neuron-specific Gata2 expression and a bias in formation of inner-ear efferent neurons over facial branchial motor neurons.