Nature Search

Author Correction: CTLA4 blockade abrogates KEAP1/STK11-related resistance to PD-(L)1 inhibitors

Ferdinandos Skoulidis
Haniel A. Araujo
John V. Heymach
Amendments and CorrectionsOpen Access27 Feb 2025
Nature

Volume: 639, P: E19
CTLA4 blockade abrogates KEAP1/STK11-related resistance to PD-(L)1 inhibitors

Alterations in the tumour suppressor genes STK11 and/or KEAP1 can identify patients with advanced non-small-cell lung cancer who are likely to benefit from combinations of PD-(L)1 and CTLA4 immune checkpoint inhibitors added to chemotherapy.

Ferdinandos Skoulidis
Haniel A. Araujo
John V. Heymach
ResearchOpen Access09 Oct 2024
Nature

Volume: 635, P: 462-471
Molecular and clinical determinants of response and resistance to rucaparib for recurrent ovarian cancer treatment in ARIEL2 (Parts 1 and 2)

The identification of biomarkers of response to PARP inhibitors can enable selection of appropriate ovarian cancer patients for treatment. In this study, the authors report clinical results and exploratory biomarker analyses from the ARIEL2 phase 2 clinical trial on the safety and efficacy of the PARP inhibitor rucaparib in patients with recurrent ovarian cancers

Elizabeth M. Swisher
Tanya T. Kwan
Iain A. McNeish
ResearchOpen Access03 May 2021
Nature Communications

Volume: 12, P: 1-13
Genomic heterogeneity of multiple synchronous lung cancer

Some patients present with multiple lung tumours but it is unclear whether these are metastases or individual lesions. Here, the authors use genomics techniques to demonstrate in six patients that multiple tumours have individual genetic profiles and represent separate tumours.

Yu Liu
Jianjun Zhang
Yanning Gao
ResearchOpen Access21 Oct 2016
Nature Communications

Volume: 7, P: 1-8
Cellular and humoral immune responses to adenovirus and p53 protein antigens in patients following intratumoral injection of an adenovirus vector expressing wild-type p53 (Ad-p53)

Nancy Yen
Constantin G Ioannides
Jack A Roth
Research15 Jun 2000
Cancer Gene Therapy

Volume: 7, P: 530-536
Nodal immune flare mimics nodal disease progression following neoadjuvant immune checkpoint inhibitors in non-small cell lung cancer

Granulomatous/sarcoid-like lesions have been reported in patients treated with immune checkpoint inhibitors (ICIs). Here the authors report the occurrence of “nodal immune flare”, an apparent radiological cancer progression in the nodes characterized by the absence of cancer and the presence of non-caseating granulomas, in patients with non-small cell lung cancer following neoadjuvant ICI treatment.

Tina Cascone
Annikka Weissferdt
Boris Sepesi
ResearchOpen Access19 Aug 2021
Nature Communications

Volume: 12, P: 1-15
Accelerated functional brain aging in pre-clinical familial Alzheimer’s disease

Alzheimer’s disease has been associated with increased structural brain aging. Here the authors describe a model that predicts brain aging from resting state functional connectivity data, and demonstrate this is accelerated in individuals with pre-clinical familial Alzheimer’s disease.

Julie Gonneaud
Alex T. Baria
Etienne Vachon-Presseau
ResearchOpen Access09 Sept 2021
Nature Communications

Volume: 12, P: 1-17
MTAP deficiency creates an exploitable target for antifolate therapy in 9p21-loss cancers

The deficiency of MTAP, an enzyme of the adenine salvage pathway, occurs in some cancers. Here the authors perform a small cohort phase II clinical trial with metastatic MTAP-deficient urothelial cancer (UC) and show an increased overall response when comparing to MTAP-proficient UC patients.

Omar Alhalabi
Jianfeng Chen
Jianjun Gao
ResearchOpen Access04 Apr 2022
Nature Communications

Volume: 13, P: 1-12
The histologic phenotype of lung cancers is associated with transcriptomic features rather than genomic characteristics

The molecular determinants of lung cancer histologic subtypes are not well understood. Here the authors analyze lung cancers of mixed histology and find that histologic subtypes are associated with transcriptomic features rather than genomic profiles in most tumors.

Ming Tang
Hussein A. Abbas
Jianjun Zhang
ResearchOpen Access06 Dec 2021
Nature Communications

Volume: 12, P: 1-11
Multi-region exome sequencing reveals genomic evolution from preneoplasia to lung adenocarcinoma

There has been a drastic increase in detection of lung nodules, many of which are precancers, preinvasive, minimally invasive or sometimes invasive lung cancers. Here, Hu et al. perform multi-region exome sequencing to discern the evolutional trajectory from precancers to invasive lung cancers.

Xin Hu
Junya Fujimoto
Jianjun Zhang
ResearchOpen Access05 Jul 2019
Nature Communications

Volume: 10, P: 1-10
Comprehensive T cell repertoire characterization of non-small cell lung cancer

Relevant features of T cell repertoire in human cancer remain to be delineated. Here the authors show, by TCR sequencing in a large cohort of lung cancer patients, that while a majority of T cell clones are shared between tumor and adjacent lung tissue, less frequent tumor-unique T cell clones correlate with worse prognosis.

Alexandre Reuben
Jiexin Zhang
Jianjun Zhang
ResearchOpen Access30 Jan 2020
Nature Communications

Volume: 11, P: 1-13
Neoadjuvant chemotherapy plus nivolumab with or without ipilimumab in operable non-small cell lung cancer: the phase 2 platform NEOSTAR trial

The combination of neoadjuvant nivolumab, ipilimumab and chemotherapy showed promising efficacy in patients with resectable non-small cell lung cancer, with higher tumor immune cell infiltration and tertiary lymphoid structures after treatment compared with neoadjuvant nivolumab plus chemotherapy.

Tina Cascone
Cheuk H. Leung
Boris Sepesi
ResearchOpen Access16 Mar 2023
Nature Medicine

Volume: 29, P: 593-604
Neoadjuvant nivolumab or nivolumab plus ipilimumab in operable non-small cell lung cancer: the phase 2 randomized NEOSTAR trial

Neoadjuvant treatment with nivolumab plus ipilimumab is well tolerated and demonstrates clinical efficacy in patients with early stage lung cancer.

Tina Cascone
William N. William Jr
Boris Sepesi
Research18 Feb 2021
Nature Medicine

Volume: 27, P: 504-514
Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance

The mechanisms of PARP inhibitor (PARPi) resistance are poorly understood. Here the authors employ a CRISPR mutagenesis approach to identify PARP1 mutants causing PARPi resistance and find that PARP1 mutations are tolerated in BRCA1 mutated cells, suggesting alternative resistance mechanisms.

Stephen J. Pettitt
Dragomir B. Krastev
Christopher J. Lord
ResearchOpen Access10 May 2018
Nature Communications

Volume: 9, P: 1-14
Single-cell analyses reveal increased intratumoral heterogeneity after the onset of therapy resistance in small-cell lung cancer

Stewart et al. use circulating tumor cell-derived xenografts from patients with small-cell lung cancer to study tumor heterogeneity following the onset of therapeutic resistance.

C. Allison Stewart
Carl M. Gay
Lauren Averett Byers
Research17 Feb 2020
Nature Cancer

Volume: 1, P: 423-436
Multiregion gene expression profiling reveals heterogeneity in molecular subtypes and immunotherapy response signatures in lung cancer

Won-Chul Lee
Lixia Diao
Jianjun Zhang
Research06 Feb 2018
Modern Pathology

Volume: 31, P: 947-955
Genetic variation in the TNF/TRAF2/ASK1/p38 kinase signaling pathway as markers for postoperative pulmonary complications in lung cancer patients

Michelle A. T. Hildebrandt
Jack A. Roth
Xifeng Wu
ResearchOpen Access13 Jul 2015
Scientific Reports

Volume: 5, P: 1-8
Author Correction: Multi-region exome sequencing reveals genomic evolution from preneoplasia to lung adenocarcinoma

Xin Hu
Junya Fujimoto
Jianjun Zhang
Amendments and CorrectionsOpen Access12 May 2021
Nature Communications

Volume: 12, P: 1
BRCA-DIRECT digital pathway for diagnostic germline genetic testing within a UK breast oncology setting: a randomised, non-inferiority trial

Bethany Torr
Christopher Jones
Clare Turnbull
ResearchOpen Access01 Oct 2024
British Journal of Cancer

Volume: 131, P: 1506-1515
A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer’s disease

Site-specific hyperphosphorylations of tau in the cerebrospinal fluid change with disease course, and correlate with pathology and cognitive decline in dominantly inherited Alzheimer’s disease.

Nicolas R. Barthélemy
Yan Li
Xiong Xu
Research11 Mar 2020
Nature Medicine

Volume: 26, P: 398-407
Integrated genomic and molecular characterization of cervical cancer

This paper describes molecular subtypes of cervical cancers, including squamous cell carcinoma and adenocarcinoma clusters defined by HPV status and molecular features, and distinct molecular pathways that are activated in cervical carcinomas caused by different somatic alterations and HPV types.

Robert D. Burk
Zigui Chen
David Mutch
ResearchOpen Access23 Jan 2017
Nature

Volume: 543, P: 378-384
Induction of p53-regulated genes in lung cancer cells: implications of the mechanism for adenoviral p53-mediated apoptosis

Jian Gu
Lidong Zhang
Bingliang Fang
Research15 Dec 2003
Oncogene

Volume: 23, P: 1300-1307
Role of neoadjuvant chemoimmunotherapy for resectable NSCLC

Immune-checkpoint inhibitors have revolutionized the treatment of patients with non-small-cell lung cancer (NSCLC). Recently, indications for immune-checkpoint inhibitors have expanded from advanced-stage NSCLC to adjuvant, and now neoadjuvant, therapy for resectable NSCLC, with three cycles of preoperative chemoimmunotherapy achieving superior pathological complete response rates and event-free survival compared with chemotherapy alone in the phase III CheckMate 816 trial.

Boris Sepesi
Stephen G. Swisher
News & Views18 May 2022
Nature Reviews Clinical Oncology

Volume: 19, P: 497-498
Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid

Perivascular and leptomeningeal macrophages, collectively termed here parenchymal border macrophages, are shown to regulate flow dynamics of cerebrospinal fluid, implicating this cell population as new therapeutic targets in neurological diseases such as Alzheimer’s.

Antoine Drieu
Siling Du
Jonathan Kipnis
Research09 Nov 2022
Nature

Volume: 611, P: 585-593
Positron emission tomography and magnetic resonance imaging methods and datasets within the Dominantly Inherited Alzheimer Network (DIAN)

The Dominantly Inherited Alzheimer Network neuroimaging repository is a free resource consisting of PET and MRI scans from 533 individuals across 206 families who are deeply phenotyped with genetic, clinical, cognitive and biofluid sampling.

Nicole S. McKay
Brian A. Gordon
Christian la Fougère
ResearchOpen Access10 Jul 2023
Nature Neuroscience

Volume: 26, P: 1449-1460
Ensuring fair, safe, and interpretable artificial intelligence-based prediction tools in a real-world oncological setting

George, Ellis et al. develop an explainable artificial intelligence model to predict 30-day emergency department admission in patients with cancer undergoing treatment. The authors describe an approach to monitor the model after deployment, which provides ongoing readouts of data consistency and model behavior.

Renee George
Benjamin Ellis
Chris Sidey-Gibbons
ResearchOpen Access22 Jun 2023
Communications Medicine

Volume: 3, P: 1-8
Identification of three new ‘Candidatus Liberibacter solanacearum’ haplotypes in four psyllid species (Hemiptera: Psylloidea)

Kylie D. Swisher Grimm
David R. Horton
Brian A. Charlton
ResearchOpen Access30 Nov 2022
Scientific Reports

Volume: 12, P: 1-15
Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease

In a longitudinal cohort of familial Alzheimer’s disease patients, the rate of change of blood biomarker levels identifies disease carriers much earlier than absolute levels and predicts both neurodegeneration and cognitive decline.

Oliver Preische
Stephanie A. Schultz
Xiong Xu
Research21 Jan 2019
Nature Medicine

Volume: 25, P: 277-283
Therapeutic targeting of the PI4K2A/PKR lysosome network is critical for misfolded protein clearance and survival in cancer cells

Apar Pataer
Bulent Ozpolat
Stephen G. Swisher
ResearchOpen Access25 Sept 2019
Oncogene

Volume: 39, P: 801-813
An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations

Dube et al. generated an atlas of human brain circular RNA (circRNA) expression in individuals with and without Alzheimer disease (AD). They demonstrated circRNA expression correlates with AD severity, even before substantial clinical symptom onset.

Umber Dube
Jorge L Del-Aguila
Carlos Cruchaga
Research07 Oct 2019
Nature Neuroscience

Volume: 22, P: 1903-1912
Influence of induction chemotherapy in trimodality therapy-eligible oesophageal cancer patients: secondary analysis of a randomised trial

Yusuke Shimodaira
Rebecca S Slack
Jaffer A Ajani
ResearchOpen Access12 Dec 2017
British Journal of Cancer

Volume: 118, P: 331-337
Anti-phosphorylated histone H3 expression in Barrett's esophagus, low-grade dysplasia, high-grade dysplasia, and adenocarcinoma

Mahmoud Goodarzi
Arlene M Correa
Dipen M Maru
Research04 Sept 2009
Modern Pathology

Volume: 22, P: 1612-1621
Role for the double-stranded RNA activated protein kinase PKR in E2F-1-induced apoptosis

Stephan A Vorburger
Abujiang Pataer
Kelly K Hunt
Research12 Sept 2002
Oncogene

Volume: 21, P: 6278-6288
The chemosensory receptors of codling moth Cydia pomonella–expression in larvae and adults

William B. Walker III
Francisco Gonzalez
Peter Witzgall
ResearchOpen Access23 Mar 2016
Scientific Reports

Volume: 6, P: 1-15
Nuclear expression of Gli-1 is predictive of pathologic complete response to chemoradiation in trimodality treated oesophageal cancer patients

Roopma Wadhwa
Xuemei Wang
Jaffer A Ajani
ResearchOpen Access20 Jul 2017
British Journal of Cancer

Volume: 117, P: 648-655
Early-stage pulmonary adenocarcinoma (T1N0M0): a clinical, radiological, surgical, and pathological correlation of 104 cases. The MD Anderson Cancer Center Experience

Annikka Weissferdt
Neda Kalhor
Cesar A Moran
Research29 Mar 2013
Modern Pathology

Volume: 26, P: 1065-1075

Search

Author Correction: CTLA4 blockade abrogates KEAP1/STK11-related resistance to PD-(L)1 inhibitors

CTLA4 blockade abrogates KEAP1/STK11-related resistance to PD-(L)1 inhibitors

Molecular and clinical determinants of response and resistance to rucaparib for recurrent ovarian cancer treatment in ARIEL2 (Parts 1 and 2)

Genomic heterogeneity of multiple synchronous lung cancer

Cellular and humoral immune responses to adenovirus and p53 protein antigens in patients following intratumoral injection of an adenovirus vector expressing wild-type p53 (Ad-p53)

Nodal immune flare mimics nodal disease progression following neoadjuvant immune checkpoint inhibitors in non-small cell lung cancer

Accelerated functional brain aging in pre-clinical familial Alzheimer’s disease

MTAP deficiency creates an exploitable target for antifolate therapy in 9p21-loss cancers

The histologic phenotype of lung cancers is associated with transcriptomic features rather than genomic characteristics

Multi-region exome sequencing reveals genomic evolution from preneoplasia to lung adenocarcinoma

Comprehensive T cell repertoire characterization of non-small cell lung cancer

Neoadjuvant chemotherapy plus nivolumab with or without ipilimumab in operable non-small cell lung cancer: the phase 2 platform NEOSTAR trial

Neoadjuvant nivolumab or nivolumab plus ipilimumab in operable non-small cell lung cancer: the phase 2 randomized NEOSTAR trial

Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance

Single-cell analyses reveal increased intratumoral heterogeneity after the onset of therapy resistance in small-cell lung cancer

Multiregion gene expression profiling reveals heterogeneity in molecular subtypes and immunotherapy response signatures in lung cancer

Genetic variation in the TNF/TRAF2/ASK1/p38 kinase signaling pathway as markers for postoperative pulmonary complications in lung cancer patients

Author Correction: Multi-region exome sequencing reveals genomic evolution from preneoplasia to lung adenocarcinoma

BRCA-DIRECT digital pathway for diagnostic germline genetic testing within a UK breast oncology setting: a randomised, non-inferiority trial

A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer’s disease

Integrated genomic and molecular characterization of cervical cancer

Induction of p53-regulated genes in lung cancer cells: implications of the mechanism for adenoviral p53-mediated apoptosis

Role of neoadjuvant chemoimmunotherapy for resectable NSCLC

Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid

Positron emission tomography and magnetic resonance imaging methods and datasets within the Dominantly Inherited Alzheimer Network (DIAN)

Ensuring fair, safe, and interpretable artificial intelligence-based prediction tools in a real-world oncological setting

Identification of three new ‘Candidatus Liberibacter solanacearum’ haplotypes in four psyllid species (Hemiptera: Psylloidea)

Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease

Therapeutic targeting of the PI4K2A/PKR lysosome network is critical for misfolded protein clearance and survival in cancer cells

An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations

Influence of induction chemotherapy in trimodality therapy-eligible oesophageal cancer patients: secondary analysis of a randomised trial

Anti-phosphorylated histone H3 expression in Barrett's esophagus, low-grade dysplasia, high-grade dysplasia, and adenocarcinoma

Role for the double-stranded RNA activated protein kinase PKR in E2F-1-induced apoptosis

The chemosensory receptors of codling moth Cydia pomonella–expression in larvae and adults

Nuclear expression of Gli-1 is predictive of pathologic complete response to chemoradiation in trimodality treated oesophageal cancer patients

Early-stage pulmonary adenocarcinoma (T1N0M0): a clinical, radiological, surgical, and pathological correlation of 104 cases. The MD Anderson Cancer Center Experience

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