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SARS-CoV-2 induces robust germinal center CD4 T follicular helper cell responses in rhesus macaques

Induction of CD4 T follicular helper (Tfh) cells is important for antibody responses to viral infections. Here, the authors show in a rhesus macaque model of mild COVID-19 that SARS-CoV-2 infection results in transient accumulation of proliferating Tfh cells with a Th1 profile in peripheral blood and generation of germinal center Tfh cells specific for viral proteins.

Yashavanth Shaan Lakshmanappa
Sonny R. Elizaldi
Smita S. Iyer
ResearchOpen Access22 Jan 2021
Nature Communications

Volume: 12, P: 1-14
A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells

Heligmosomoides polygyrus can activate mammalian TGF-β signalling pathways, but how it does so is not known. Here the authors identify and isolate a H. polygyrus TFG-β mimic that can bind both mammalian TGF-β receptor subunits, activate Smad signalling and generate inducible regulatory T cells.

Chris J. C. Johnston
Danielle J. Smyth
Rick M. Maizels
ResearchOpen Access23 Nov 2017
Nature Communications

Volume: 8, P: 1-13
Vitamin A deficiency impairs neutrophil-mediated control of Salmonella via SLC11A1 in mice

Vitamin A deficiency exacerbates invasive non-typhoidal Salmonella infection in mice, revealing a restrictive role for SLC11A1 in neutrophils.

Kristen L. Lokken-Toyli
Vladimir E. Diaz-Ochoa
Renée M. Tsolis
ResearchOpen Access19 Feb 2024
Nature Microbiology

Volume: 9, P: 727-736
Physiological microbial exposure transiently inhibits mouse lung ILC2 responses to allergens

Here the authors show that mice exposed to a variety of pathogens initially have impaired innate type 2 responses to lung allergens, but reactivity resets over time, indicating that microbial experience does not stably inhibit innate immunity to allergens.

Katharine E. Block
Koji Iijima
Stephen C. Jameson
Research21 Nov 2022
Nature Immunology

Volume: 23, P: 1703-1713
Paneth cells: targets of friendly fire

Severe intestinal pathology associated with infection with Toxoplasma gondii is a result of the loss of Paneth cells, an unexpected side effect of the secretion of IFN-γ by protective CD4⁺ T cells in the intestinal mucosa.

Stephen J McSorley
Charles L Bevins
News & Views18 Jan 2013
Nature Immunology

Volume: 14, P: 114-116
SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway

The Omicron variant evades vaccine-induced neutralization but also fails to form syncytia, shows reduced replication in human lung cells and preferentially uses a TMPRSS2-independent cell entry pathway, which may contribute to enhanced replication in cells of the upper airway. Altered fusion and cell entry characteristics are linked to distinct regions of the Omicron spike protein.

Brian J. Willett
Joe Grove
Emma C. Thomson
ResearchOpen Access07 Jul 2022
Nature Microbiology

Volume: 7, P: 1161-1179
The Ets transcription factor Spi-B is essential for the differentiation of intestinal microfold cells

Intestinal microfold (M) cells actively capture luminal antigens and move them by transcytosis to initiate immune responses. Ohno and colleagues show that the Ets transcription factor Spi-B is necessary for M-cell differentiation.

Takashi Kanaya
Koji Hase
Hiroshi Ohno
Research17 Jun 2012
Nature Immunology

Volume: 13, P: 729-736
Relationship between computed tomography-derived body composition, sex, and post-operative complications in patients with colorectal cancer

Arwa S. Almasaudi
Ross D. Dolan
Donald C. McMillan
Research11 Mar 2019
European Journal of Clinical Nutrition

Volume: 73, P: 1450-1457
The relationship between tumour necrosis, systemic inflammation, body composition and survival in patients with colon cancer

Ross D. Dolan
Kathryn Pennel
Joanne Edwards
ResearchOpen Access05 Feb 2025
BJC Reports

Volume: 3, P: 1-10
NOD1 and NOD2 signalling links ER stress with inflammation

A novel link between the unfolded protein response and NOD1/2 innate immune signalling, showing that NOD1/2 are required for ER-stress-induced IL-6 production in response to infection with Brucella abortus.

A. Marijke Keestra-Gounder
Mariana X. Byndloss
Renée M. Tsolis
Research23 Mar 2016
Nature

Volume: 532, P: 394-397
Immune profiling with a Salmonella Typhi antigen microarray identifies new diagnostic biomarkers of human typhoid

Li Liang
Silvia Juarez
Philip L. Felgner
ResearchOpen Access09 Jan 2013
Scientific Reports

Volume: 3, P: 1-10
The role of the systemic inflammatory response in predicting outcomes in patients with operable cancer: Systematic review and meta-analysis

Ross D. Dolan
Jason Lim
Donald C. McMillan
ResearchOpen Access01 Dec 2017
Scientific Reports

Volume: 7, P: 1-31
The prognostic value of systemic inflammation in patients undergoing surgery for colon cancer: comparison of composite ratios and cumulative scores

Ross D Dolan
Stephen T McSorley
Donald C McMillan
ResearchOpen Access23 May 2018
British Journal of Cancer

Volume: 119, P: 40-51
A comparison of the prognostic value of composite ratios and cumulative scores in patients with operable rectal cancer

Ross D. Dolan
Muhammed Alwahid
Donald C. McMillan
ResearchOpen Access21 Oct 2020
Scientific Reports

Volume: 10, P: 1-13
The relationship between ¹⁸F-FDG-PETCT-derived tumour metabolic activity, nutritional risk, body composition, systemic inflammation and survival in patients with lung cancer

Ross D. Dolan
John D. Maclay
Donald C. McMillan
ResearchOpen Access30 Nov 2020
Scientific Reports

Volume: 10, P: 1-10
Lifestyle intervention in obese pregnancy and cardiac remodelling in 3-year olds: children of the UPBEAT RCT

Paul D. Taylor
Haotian Gu
Lynne Greenwood
ResearchOpen Access12 Oct 2022
International Journal of Obesity

Volume: 46, P: 2145-2155
The relationship between right-sided tumour location, tumour microenvironment, systemic inflammation, adjuvant therapy and survival in patients undergoing surgery for colon and rectal cancer

Meera Patel
Stephen T McSorley
Donald C McMillan
ResearchOpen Access16 Jan 2018
British Journal of Cancer

Volume: 118, P: 705-712

Search

SARS-CoV-2 induces robust germinal center CD4 T follicular helper cell responses in rhesus macaques

A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells

Vitamin A deficiency impairs neutrophil-mediated control of Salmonella via SLC11A1 in mice

Physiological microbial exposure transiently inhibits mouse lung ILC2 responses to allergens

Paneth cells: targets of friendly fire

SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway

The Ets transcription factor Spi-B is essential for the differentiation of intestinal microfold cells

Relationship between computed tomography-derived body composition, sex, and post-operative complications in patients with colorectal cancer

The relationship between tumour necrosis, systemic inflammation, body composition and survival in patients with colon cancer

NOD1 and NOD2 signalling links ER stress with inflammation

Immune profiling with a Salmonella Typhi antigen microarray identifies new diagnostic biomarkers of human typhoid

The role of the systemic inflammatory response in predicting outcomes in patients with operable cancer: Systematic review and meta-analysis

The prognostic value of systemic inflammation in patients undergoing surgery for colon cancer: comparison of composite ratios and cumulative scores

A comparison of the prognostic value of composite ratios and cumulative scores in patients with operable rectal cancer

The relationship between ¹⁸F-FDG-PETCT-derived tumour metabolic activity, nutritional risk, body composition, systemic inflammation and survival in patients with lung cancer

Lifestyle intervention in obese pregnancy and cardiac remodelling in 3-year olds: children of the UPBEAT RCT

The relationship between right-sided tumour location, tumour microenvironment, systemic inflammation, adjuvant therapy and survival in patients undergoing surgery for colon and rectal cancer

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