Nature Search

A map of blood regulatory variation in South Africans enables GWAS interpretation

This study maps regulatory variation in blood using whole-genome and transcriptome data from 614 South Africans, providing a resource to aid the interpretation of genome-wide association studies in African populations.

Stephane E. Castel
Furahini D. Tluway
Michèle Ramsay
ResearchOpen Access11 Jun 2025
Nature Genetics

Volume: 57, P: 1628-1637
Short- and long-read metagenomics of urban and rural South African gut microbiomes reveal a transitional composition and undescribed taxa

In this study, Wits and Stanford researchers use short- and long-read DNA sequencing to profile the gut microbiome of women living in rural and urban South Africa and identify transitional composition, high inter-individual diversity, and many undescribed taxa.

Fiona B. Tamburini
Dylan Maghini
Ami S. Bhatt
ResearchOpen Access22 Feb 2022
Nature Communications

Volume: 13, P: 1-18
Expanding the human gut microbiome atlas of Africa

A cross-sectional study from four African countries shows the importance of investigating the gut microbiome in previously under-represented populations and provides a framework for equitable microbiome research.

Dylan G. Maghini
Ovokeraye H. Oduaran
Scott Hazelhurst
ResearchOpen Access29 Jan 2025
Nature

Volume: 638, P: 718-728
Meta-analysis of sub-Saharan African studies provides insights into genetic architecture of lipid traits

Genetic associations and polygenic scores for lipid traits have low transferability to African individuals. Here, the authors perform a large sub-Sarahan African lipid GWAS and find that larger datasets and better global representation in discovery GWAS help to bridge this gap.

Ananyo Choudhury
Jean-Tristan Brandenburg
Michèle Ramsay
ResearchOpen Access11 May 2022
Nature Communications

Volume: 13, P: 1-13
Strengthening Africa’s brain health and economic resilience

The authors present a 5-year action plan that prioritizes high-impact, practical interventions in brain health across six key areas—to safeguard the continent’s health and economic stability alongside projected demographic shifts.

Mie Rizig
Connor McLaughlin
George Vradenburg
Reviews07 Aug 2025
Nature Medicine

Volume: 31, P: 2506-2517
Genome-wide association study meta-analysis of blood pressure traits and hypertension in sub-Saharan African populations: an AWI-Gen study

Hypertension is a major risk factor for cardiovascular disease prevalent in Africa. Here the authors report a genome-wide study providing insights into the genetics and physiology of blood pressure variation in African populations.

Surina Singh
Ananyo Choudhury
Michèle Ramsay
ResearchOpen Access16 Dec 2023
Nature Communications

Volume: 14, P: 1-14
Genetic substructure and complex demographic history of South African Bantu speakers

Despite linguistic and geographic diversity in South Eastern Bantu-speaking (SEB) groups of South Africa, genetic variation in these groups has not been investigated in depth. Here, the authors analyse genome-wide data from 5056 individuals, providing insights into demographic history across SEB groups.

Dhriti Sengupta
Ananyo Choudhury
Michèle Ramsay
ResearchOpen Access07 Apr 2021
Nature Communications

Volume: 12, P: 1-13
Author Correction: Meta-analysis of sub-Saharan African studies provides insights into genetic architecture of lipid traits

Ananyo Choudhury
Jean-Tristan Brandenburg
Michèle Ramsay
Amendments and CorrectionsOpen Access02 Aug 2022
Nature Communications

Volume: 13, P: 1-2
The African Genome Variation Project shapes medical genetics in Africa

The African Genome Variation Project contains the whole-genome sequences of 320 individuals and dense genotypes on 1,481 individuals from sub-Saharan Africa; it enables the design and interpretation of genomic studies, with implications for finding disease loci and clues to human origins.

Deepti Gurdasani
Tommy Carstensen
Manjinder S. Sandhu
ResearchOpen Access03 Dec 2014
Nature

Volume: 517, P: 327-332
SARS-CoV-2 correlates of protection from infection against variants of concern

SARS-CoV-2 variant-specific neutralizing antibodies (nAbs) mediate protection against infection by the cognate variant to distinct extents, while the majority of protection elicited by natural infection is not mediated by nAbs.

Kaiyuan Sun
Jinal N. Bhiman
Nicole Wolter
Research26 Jul 2024
Nature Medicine

Volume: 30, P: 2805-2812
Rapidly shifting immunologic landscape and severity of SARS-CoV-2 in the Omicron era in South Africa

Emergence of the Omicron BA.1/2 SARS-CoV-2 subvariants led to a wave of infection South Africa. Here, the authors use serological data from a prospective household study to characterise infection rates in the context of diverse immune histories following vaccination and exposure to different variants.

Kaiyuan Sun
Stefano Tempia
Floidy Wafawanaka
ResearchOpen Access16 Jan 2023
Nature Communications

Volume: 14, P: 1-13
Association of alcohol use and multimorbidity among adults aged 40 years and above in rural South Africa

Mafuno G. Mpinganjira
Tobias Chirwa
Joel Msafiri Francis
ResearchOpen Access14 May 2023
Scientific Reports

Volume: 13, P: 1-11
The immuno-oncology race: myths and emerging realities

This article analyses the huge volume of clinical trial activity for immune checkpoint inhibitors, and discusses the development of the market and strategic trends for immuno-oncology therapies in general.

Stephen Cavnar
Pedro Valencia
Valery Panier
Comments & Opinion02 Feb 2017
Nature Reviews Drug Discovery

Volume: 16, P: 83-84
Cognitive differences associated with HIV serostatus and antiretroviral therapy use in a population-based sample of older adults in South Africa

Stephen B. Asiimwe
Meagan Farrell
Till Bärnighausen
ResearchOpen Access06 Oct 2020
Scientific Reports

Volume: 10, P: 1-14
Genome-wide association study of population-standardised cognitive performance phenotypes in a rural South African community

A genome-wide association study for five cognitive phenotypes in a rural South African community suggests several variants associated with general cognition and domain-specific cognitive pathways in this cohort.

Cassandra C. Soo
Jean-Tristan Brandenburg
Ananyo Choudhury
ResearchOpen Access27 Mar 2023
Communications Biology

Volume: 6, P: 1-13

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