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Cellular heterogeneity of pluripotent stem cell-derived cardiomyocyte grafts is mechanistically linked to treatable arrhythmias

Selvakumar, Clayton et al. use a porcine model of myocardial infarction and PSC-CM transplantation and identify atrial and pacemaker-like cardiomyocytes as the cause of engraftment arrhythmias and surface marker signatures to distinguish between arrhythmogenic and non-arrhythmogenic cardiomyocytes.

Dinesh Selvakumar
Zoe E. Clayton
James J. H. Chong
ResearchOpen Access06 Feb 2024
Nature Cardiovascular Research

Volume: 3, P: 145-165
MKP5, a new member of the MAP kinase phosphatase family, which selectively dephosphorylates stress-activated kinases

Aspasia Theodosiou
Anna Smith
Alan Ashworth
Research30 Nov 1999
Oncogene

Volume: 18, P: 6981-6988
Characterization of human embryonic stem cells with features of neoplastic progression

Werbowetski-Ogilvie et al. show that cultured human embryonic stem (hES) cells that appear normal may in fact be partially transformed. Two such lines are found to have aberrant growth and differentiation properties and submicroscopic chromosomal abnormalities.

Tamra E Werbowetski-Ogilvie
Marc Bossé
Mickie Bhatia
Research04 Jan 2009
Nature Biotechnology

Volume: 27, P: 91-97

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