Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–6 of 6 results
Advanced filters: Author: Steve Lianoglou Clear advanced filters

  • van Lengerich et al. developed a human TREM2 antibody with a transport vehicle (ATV) that improves brain exposure and biodistribution in mouse models. ATV:TREM2 promotes microglial energetic capacity and metabolism via mitochondrial pathways.

    • Bettina van Lengerich
    • Lihong Zhan
    • Kathryn M. Monroe
    ResearchOpen Access
    Nature Neuroscience
    Volume: 26, P: 416-429

  • PD-L1, the ligand for T-cell inhibitory receptor PD-1, can be expressed by various cell types in the tumour microenvironment. Here, the authors show that, in mouse models, the expression of PD-L1 from both cancerous and normal host immune cells is important for suppressing anti-tumour immune responses.

    • Janet Lau
    • Jeanne Cheung
    • Maike Schmidt
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-11

  • Testosterone deficiency is associated with autoimmunity and increased B cell numbers, but the underlying mechanism is unclear. Here the authors show that testosterone may modulate the production of B cell survival factor BAFF by fibroblastic reticular cells via regulation of splenic neurotransmitter levels.

    • Anna S. Wilhelmson
    • Marta Lantero Rodriguez
    • Åsa Tivesten
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13

  • In humans, TGFβ signalling is associated with lack of response to immunotherapy in immune-excluded tumours; in mouse models of this immune phenotype, robust tumour infiltration by T cells and tumour regression are observed only when checkpoint inhibition is combined with inhibition of TGFβ signalling.

    • Sanjeev Mariathasan
    • Shannon J. Turley
    • Thomas Powles
    Research
    Nature
    Volume: 554, P: 544-548

  • Large-scale analyses of the drug sensitivity of cancer cell lines have been previously reported to yield conflicting conclusions; this Analysis uses independently generated data to demonstrate that consistency can be achieved if key laboratory and data analysis practices are considered when future studies are undertaken.

    • Peter M. Haverty
    • Eva Lin
    • Richard Bourgon
    Research
    Nature
    Volume: 533, P: 333-337