Nature Search

A Physiological Role for Amyloid Beta Protein: Enhancement of Learning and Memory

John Morley
Susan Farr
Lin Xu
ResearchOpen Access25 Jul 2008
Nature Precedings

P: 1
Studying Chinook salmon in northern river ecosystems through ecological methods and Indigenous, Teslin Tlingit knowledge

Teslin Tlingit knowledge and ecological methods shed light on Chinook salmon in northern river ecosystems, demonstrating links between the health of salmon, riparian forests, bears, and wider social-ecological systems in the Yukon.

Jared W. H. Connoy
Gillian Rourke
Steven M. Vamosi
ResearchOpen Access19 Dec 2024
Communications Biology

Volume: 7, P: 1-14
A novel dimer configuration revealed by the crystal structure at 2.4 Å resolution of human interleukin-5

Michael V. Milburn
Anne M. Hassell
Timothy N. C. Wells
Research13 May 1993
Nature

Volume: 363, P: 172-176
Evidence for opiate receptors on pituicytes

Stafford L. Lightman
Mary Ninkovic
Leslie L. Iversen
Research15 Sept 1983
Nature

Volume: 305, P: 235-236
Mapping genomic loci implicates genes and synaptic biology in schizophrenia

A genome-wide association study including over 76,000 individuals with schizophrenia and over 243,000 control individuals identifies common variant associations at 287 genomic loci, and further fine-mapping analyses highlight the importance of genes involved in synaptic processes.

Vassily Trubetskoy
Antonio F. Pardiñas
Jim van Os
Research08 Apr 2022
Nature

Volume: 604, P: 502-508
Large clonal expansions of CD8⁺ T cells in acute infectious mononucleosis

Margaret F.C. Callan
Neil Steven
Andrew J. McMichael
Research01 Aug 1996
Nature Medicine

Volume: 2, P: 906-911
Suppression of in vitro haematopoiesis following human immunodeficiency virus infection

Robert E. Donahue
Margaret M. Johnson
Jerome E. Groopman
Research01 Mar 1987
Nature

Volume: 326, P: 200-203
Anxiolytic-Like Action of Neuropeptide Y: Mediation by Y1 Receptors in Amygdala, and Dissociation from Food Intake Effects

Markus Heilig
Sarah McLeod
Karen T. Britton
Research01 Jun 1993
Neuropsychopharmacology

Volume: 8, P: 357-363
Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes

Genome-wide association analyses identify new risk loci for heart failure and its subtypes, extending understanding of the underlying biological pathways and disease mechanisms.

Albert Henry
Xiaodong Mo
R. Thomas Lumbers
ResearchOpen Access04 Mar 2025
Nature Genetics

Volume: 57, P: 815-828
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Rare coding variants in ten genes confer substantial risk for schizophrenia

Whole-exome sequencing identifies ten risk genes for schizophrenia implicated by rare protein-coding variants, a subset of which overlap with risk genes in other neurodevelopmental disorders.

Tarjinder Singh
Timothy Poterba
Mark J. Daly
Research08 Apr 2022
Nature

Volume: 604, P: 509-516
The ADP/ATP translocase drives mitophagy independent of nucleotide exchange

A CRISPR–Cas9 genetic screen shows that the adenine nucleotide translocator is required for mitophagy and that this role is independent of its nucleotide translocase activity.

Atsushi Hoshino
Wei-jia Wang
Zoltan Arany
Research16 Oct 2019
Nature

Volume: 575, P: 375-379
Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure

Heart failure is a complex syndrome that is associated with many different underlying risk factors. Here, to increase power, the authors jointly analyse cases of heart failure of different aetiologies in a genome-wide association study and identify 11 loci of which ten had not been previously reported.

Sonia Shah
Albert Henry
R. Thomas Lumbers
ResearchOpen Access09 Jan 2020
Nature Communications

Volume: 11, P: 1-12
Human distal airways contain a multipotent secretory cell that can regenerate alveoli

Human respiratory bronchioles contain a unique population of secretory cells called respiratory airway secretory cells that are distinct from the cells in the larger proximal airways, and act as unidirectional progenitors for alveolar type 2 cells.

Maria C. Basil
Fabian L. Cardenas-Diaz
Edward E. Morrisey
Research30 Mar 2022
Nature

Volume: 604, P: 120-126
Plakophilin-2 is required for transcription of genes that control calcium cycling and cardiac rhythm

It is believed that mutations in desmosomal adhesion complex protein plakophilin 2 (PKP2) cause arrhythmia due to loss of cell-cell communication. Here the authors show that PKP2 controls the expression of proteins involved in calcium cycling in adult mouse hearts, and that lack of PKP2 can cause arrhythmia in a structurally normal heart.

Marina Cerrone
Jerome Montnach
Mario Delmar
ResearchOpen Access24 Jul 2017
Nature Communications

Volume: 8, P: 1-16
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Openshaw and colleagues find myeloid inflammation and complement activation signatures in patients with long COVID who were previously hospitalized.

Felicity Liew
Claudia Efstathiou
J. Eunice Zhang
ResearchOpen Access08 Apr 2024
Nature Immunology

Volume: 25, P: 607-621
Multi-ethnic genome-wide association study for atrial fibrillation

This large, multi-ethnic genome-wide association study identifies 97 loci significantly associated with atrial fibrillation. These loci are enriched for genes involved in cardiac development, electrophysiology, structure and contractile function.

Carolina Roselli
Mark D. Chaffin
Patrick T. Ellinor
Research11 Jun 2018
Nature Genetics

Volume: 50, P: 1225-1233
Vitamin D: effects on childhood health and disease

Understanding the role of vitamin D in health and disease is an important issue in the nutritional management of children. This Review focuses on the effects of vitamin D on key disease states in children, including acute and chronic illnesses, a topic that has received minimal coverage in current guidelines.

Steven A. Abrams
Jorge A. Coss-Bu
Dov Tiosano
Reviews05 Feb 2013
Nature Reviews Endocrinology

Volume: 9, P: 162-170
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization

Christopher Newton-Cheh and colleagues report genome-wide association analyses for QT interval, an electrocardiographic measure reflecting myocardial repolarization, in 100,000 individuals. They identify 35 loci associated with QT interval and highlight a role for calcium regulation in myocardial repolarization.

Dan E Arking
Sara L Pulit
Christopher Newton-Cheh
Research22 Jun 2014
Nature Genetics

Volume: 46, P: 826-836
Correction: Corrigendum: Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

Carl A Anderson
Gabrielle Boucher
John D Rioux
Amendments and Corrections29 Aug 2011
Nature Genetics

Volume: 43, P: 919
International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways

Primary biliary cirrhosis is an autoimmune liver disease with poor therapeutic options. Here Cordell et al. a perform meta-analysis of European genome-wide association studies identifying six novel risk loci and a number of potential therapeutic pathways.

Heather J. Cordell
Younghun Han
Katherine A. Siminovitch
ResearchOpen Access22 Sept 2015
Nature Communications

Volume: 6, P: 1-11
Clearance of Natural Surfactant Phosphatidylcholine from 3-Day-Old Rabbit Lungs: Effects of Dose and Species

Andrea Pettenazzo
Kouki Oguchi
Alan Jobe
Research01 Nov 1986
Pediatric Research

Volume: 20, P: 1139-1142
The Na⁺/Ca²⁺ exchanger NCKX4 governs termination and adaptation of the mammalian olfactory response

Here the authors identify NCKX4, a potassium-dependent Na⁺/Ca²⁺ exchanger as being necessary for rapid response termination and proper adaptation of vertebrate olfactory sensory neurons. They also report that Nckx4^−/− mice have a reduced ability to locate an odorous source and have lower body weights.

Aaron B Stephan
Steven Tobochnik
Haiqing Zhao
Research06 Nov 2011
Nature Neuroscience

Volume: 15, P: 131-137
Targeting cardiac fibrosis with engineered T cells

Adoptive transfer of CAR T cells against the fibroblast marker FAP reduces cardiac fibrosis and restores function after cardiac injury in mice, providing proof-of-principle for the development of immunotherapeutic treatments for cardiac disease.

Haig Aghajanian
Toru Kimura
Jonathan A. Epstein
Research11 Sept 2019
Nature

Volume: 573, P: 430-433
Impaired Object Recognition Memory Following Methamphetamine, but not p-Chloroamphetamine- or d-Amphetamine-Induced Neurotoxicity

Annabelle M Belcher
Steven J O'Dell
John F Marshall
Research18 May 2005
Neuropsychopharmacology

Volume: 30, P: 2026-2034
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

John Rioux and colleagues report results of a large genome-wide association meta-analysis and follow-up study of ulcerative colitis. They identify 29 new risk loci for this inflammatory disease and show that many risk loci are shared between ulcerative colitis and Crohn's disease.

Carl A Anderson
Gabrielle Boucher
John D Rioux
Research06 Feb 2011
Nature Genetics

Volume: 43, P: 246-252
Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
Amendments and CorrectionsOpen Access11 Jul 2023
Nature

Volume: 619, P: E61
Hierarchical Hidden Markov models enable accurate and diverse detection of antimicrobial resistance sequences

Steven Lakin et al. present Meta-MARC, a computational method for identifying antimicrobial resistance sequences using DNA-based Hidden Markov Models. Because of its increased sensitivity, Meta-MARC is able to detect novel antimicrobial resistance sequences that are divergent from all known sequences.

Steven M. Lakin
Alan Kuhnle
Christina Boucher
ResearchOpen Access06 Aug 2019
Communications Biology

Volume: 2, P: 1-11
Effects of a Saccharomyces cerevisiae fermentation product on liver abscesses, fecal microbiome, and resistome in feedlot cattle raised without antibiotics

Katherine L. Huebner
Jennifer N. Martin
Keith E. Belk
ResearchOpen Access22 Feb 2019
Scientific Reports

Volume: 9, P: 1-11
Experiences and attitudes of genome investigators regarding return of individual genetic test results

Rachel B. Ramoni
Amy L. McGuire
Steven Joffe
Research02 May 2013
Genetics in Medicine

Volume: 15, P: 882-887
Genome sequencing identifies “Limestone Canyon virus” as Montaño virus (Hantaviridae: Orthohantavirus montanoense) circulating in brush deermice in New Mexico

Samuel M. Goodfellow
Robert A. Nofchissey
Steven B. Bradfute
ResearchOpen Access04 Apr 2024
npj Viruses

Volume: 2, P: 1-10
Contributions of common genetic variants to risk of schizophrenia among individuals of African and Latino ancestry

Tim B. Bigdeli
Giulio Genovese
Carlos N. Pato
ResearchOpen Access07 Oct 2019
Molecular Psychiatry

Volume: 25, P: 2455-2467
Acetaminophen cytotoxicity is ameliorated in a human liver organotypic co-culture model

Leonard J. Nelson
Maria Navarro
John N. Plevris
ResearchOpen Access03 Dec 2015
Scientific Reports

Volume: 5, P: 1-12
Multimodal synergisms in host stimuli drive landing response in malaria mosquitoes

Manuela Carnaghi
Steven R. Belmain
Frances M. Hawkes
ResearchOpen Access01 Apr 2021
Scientific Reports

Volume: 11, P: 1-12
The United States COVID-19 Forecast Hub dataset

Estee Y. Cramer
Yuxin Huang
Nicholas G. Reich
ResearchOpen Access01 Aug 2022
Scientific Data

Volume: 9, P: 1-15
Effects of Altered Amygdalar Neuropeptide Y Expression on Anxiety-Related Behaviors

Stefany D Primeaux
Steven P Wilson
Marlene A Wilson
Research16 Mar 2005
Neuropsychopharmacology

Volume: 30, P: 1589-1597
Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array

Edward J Saunders
Tokhir Dadaev
Zsofia Kote-Jarai
ResearchOpen Access10 Mar 2016
British Journal of Cancer

Volume: 114, P: 945-952

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