Nature Search

Genome-wide meta-analyses of restless legs syndrome yield insights into genetic architecture, disease biology and risk prediction

Pooled and sex-specific genome-wide association analyses identify new risk loci for restless legs syndrome and candidates for drug repurposing. Machine learning models combining genetic and other information show improved risk prediction performance.

Barbara Schormair
Chen Zhao
Juliane Winkelmann
ResearchOpen Access05 Jun 2024
Nature Genetics

Volume: 56, P: 1090-1099
Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry

Emelia Benjamin and colleagues report a meta-analysis of genome-wide association study data for atrial fibrillation, a condition associated with stroke and heart failure, in five European community-based cohorts of the CHARGE consortium. They report an association in ZFHX3 to atrial fibrillation, with replication in an independent cohort from the German AF Network.

Emelia J Benjamin
Kenneth M Rice
Jacqueline C M Witteman
Research13 Jul 2009
Nature Genetics

Volume: 41, P: 879-881
Erratum: Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation

Ingrid E Christophersen
Michiel Rienstra
Patrick T Ellinor
Amendments and Corrections27 Jul 2017
Nature Genetics

Volume: 49, P: 1286
APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids

APOE4 is a strong genetic risk factor for late-onset Alzheimer’s disease. Here, the authors show that APOE4 is associated with AD features in hiPSCs-derived cerebral organoids. Isogenic conversion of APOE4 to APOE3 attenuates the AD-associated phenotype.

Jing Zhao
Yuan Fu
Guojun Bu
ResearchOpen Access02 Nov 2020
Nature Communications

Volume: 11, P: 1-14
Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation

Patrick Ellinor and colleagues report meta-analyses of common and rare variant association studies for atrial fibrillation across multiple populations. They identify 12 new loci, some of which implicate genes in atrial electrical and mechanical function.

Ingrid E Christophersen
Michiel Rienstra
Patrick T Ellinor
Research17 Apr 2017
Nature Genetics

Volume: 49, P: 946-952
Genome-wide analysis of insomnia disorder

Murray B. Stein
Michael J. McCarthy
Robert J. Ursano
Research08 Mar 2018
Molecular Psychiatry

Volume: 23, P: 2238-2250
Genetic Interactions with Age, Sex, Body Mass Index, and Hypertension in Relation to Atrial Fibrillation: The AFGen Consortium

Lu-Chen Weng
Kathryn L. Lunetta
Steven A. Lubitz
ResearchOpen Access12 Sept 2017
Scientific Reports

Volume: 7, P: 1-11
Gene-gene Interaction Analyses for Atrial Fibrillation

Honghuang Lin
Martina Mueller-Nurasyid
Patrick T. Ellinor
ResearchOpen Access08 Nov 2016
Scientific Reports

Volume: 6, P: 1-9

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Genome-wide meta-analyses of restless legs syndrome yield insights into genetic architecture, disease biology and risk prediction

Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry

Erratum: Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation

APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids

Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation

Genome-wide analysis of insomnia disorder

Genetic Interactions with Age, Sex, Body Mass Index, and Hypertension in Relation to Atrial Fibrillation: The AFGen Consortium

Gene-gene Interaction Analyses for Atrial Fibrillation

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