Suppressing the homologous recombination of repetitive DNA sequences is important for maintaining genome stability, and packaging of repeat DNA into silent chromatin was generally thought to protect it from recombination. Yeast ribosomal DNA (rDNA) repetitive sequences are shown to associate with the nuclear periphery via inner nuclear membrane proteins, and this tethering is required for rDNA stability. Sir2-dependent silencing is not sufficient to inhibit rDNA recombination.
- Karim Mekhail
- Jan Seebacher
- Danesh Moazed
