Nature Search

Mouse lemur cell atlas informs primate genes, physiology and disease

Together with an accompanying paper presenting a transcriptomic atlas of the mouse lemur, interrogation of the atlas provides a rich body of data to support the use of the organism as a model for primate biology and health.

Camille Ezran
Shixuan Liu
Mark A. Krasnow
ResearchOpen Access30 Jul 2025
Nature

Volume: 644, P: 185-196
Species selection and the role of the individual

STEVEN M. STANLEY
Research19 May 1988
Nature

Volume: 333, P: 214-215
Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8⁺ T cell responses during chronic infection

The transcriptional control of T cell exhaustion remains unclear. Wherry and colleagues show that the transcription factor T-bet regulates CD8⁺ T cell exhaustion and inhibitory receptor expression.

Charlly Kao
Kenneth J Oestreich
E John Wherry
Research29 May 2011
Nature Immunology

Volume: 12, P: 663-671
Chemokine expression predicts T cell-inflammation and improved survival with checkpoint inhibition across solid cancers

Joan Miguel Romero
Emma Titmuss
George Zogopoulos
ResearchOpen Access09 Aug 2023
npj Precision Oncology

Volume: 7, P: 1-14
Analysis of more than 400,000 women provides case-control evidence for BRCA1 and BRCA2 variant classification

BRCA1 and BRCA2 are well known breast cancer predisposition genes, however, many variants have not yet been classified for their pathogenicity. Here, the authors analyse a large combined cohort to provide evidence of variant pathogenicity.

Maria Zanti
Denise G. O’Mahony
Kyriaki Michailidou
ResearchOpen Access25 May 2025
Nature Communications

Volume: 16, P: 1-18
Cloning and expression of an inwardly rectifying ATP-regulated potassium channel

Kevin Ho
Colin G. Nichols
Steven C. Hebert
Research01 Mar 1993
Nature

Volume: 362, P: 31-38
Complete nucleotide sequence of the AIDS virus, HTLV-III

Lee Ratner
William Haseltine
Flossie Wong-Staal
Research24 Jan 1985
Nature

Volume: 313, P: 277-284
A regulatory role for TGF-β signaling in the establishment and function of the thymic medulla

Double-positive αβ thymocytes undergo negative selection on thymic epithelial cells. Ziegler and colleagues show that TGF-β limits numbers and function of medullary thymic epithelial cells, thus influencing the resultant T cell repertoire.

Mathias Hauri-Hohl
Saulius Zuklys
Steven F Ziegler
Research13 Apr 2014
Nature Immunology

Volume: 15, P: 554-561
Biological properties of a CD4 immunoadhesin

Randal A. Byrn
Joyce Mordenti
Daniel J. Capon
Research12 Apr 1990
Nature

Volume: 344, P: 667-670
Structural Proteins in Perinatal Rat Epidermis: Characterization of a High Molecular Weight Prekeratin

Steven B Hoath
Steven F Sells
William L Pickens
Research01 May 1989
Pediatric Research

Volume: 25, P: 542-547
Molecular mechanism of cyclic-nucleotide-gated channel activation

Evan H. Goulding
Gareth R. Tibbs
Steven A. Siegelbaum
Research24 Nov 1994
Nature

Volume: 372, P: 369-374
Evidence for low density holes in Jupiter’s ionosphere

Intense electromagnetic impulses induced by Jupiter’s lightning can produce both low-frequency dispersed whistler emissions and non-dispersed radio pulses. Here, the authors show Jupiter dispersed pulses associated with Jovian lightning that are evidence of low density holes in Jupiter’s ionosphere.

Masafumi Imai
Ivana Kolmašová
Steven M. Levin
ResearchOpen Access21 Jun 2019
Nature Communications

Volume: 10, P: 1-6
Re-evaluation of the linkage relationship between chromosome 11p loci and the gene for bipolar affective disorder in the Old Order Amish

John R. Kelsoe
Edward I. Ginns
Steven M. Paul
Research16 Nov 1989
Nature

Volume: 342, P: 238-243
The cell surface receptors for interleukin-1α and interleukin-1β are identical

Steven K. Dower
Shirley R. Kronheim
David L. Urdal
Research20 Nov 1986
Nature

Volume: 324, P: 266-268
Inhibition of Fc receptors on a murine lymphoid cell line by cholera exotoxin

STEVEN H. ZUCKERMAN
STEVEN D. DOUGLAS
Research29 May 1975
Nature

Volume: 255, P: 410-412
SARS-CoV-2 evolution during treatment of chronic infection

Chronic infection with SARS-CoV-2 leads to the emergence of viral variants that show reduced susceptibility to neutralizing antibodies in an immunosuppressed individual treated with convalescent plasma.

Steven A. Kemp
Dami A. Collier
Ravindra K. Gupta
Research05 Feb 2021
Nature

Volume: 592, P: 277-282
Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Sera from vaccinated individuals and some monoclonal antibodies show a modest reduction in neutralizing activity against the B.1.1.7 variant of SARS-CoV-2; but the E484K substitution leads to a considerable loss of neutralizing activity.

Dami A. Collier
Anna De Marco
Ravindra K. Gupta
Research11 Mar 2021
Nature

Volume: 593, P: 136-141
Alteration of electrical activity in molluscan neurones by cyclic nucleotides and peptide factors

STEVEN N. TREISTMAN
IRWIN B. LEVITAN
Research06 May 1976
Nature

Volume: 261, P: 62-64
Intermittent vortex structures in homogeneous isotropic turbulence

Zhen-Su She
Eric Jackson
Steven A. Orszag
Research15 Mar 1990
Nature

Volume: 344, P: 226-228
A saturated map of common genetic variants associated with human height

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

Loïc Yengo
Sailaja Vedantam
Joel N. Hirschhorn
ResearchOpen Access12 Oct 2022
Nature

Volume: 610, P: 704-712
Impaired Chemotaxis and Neutrophil (Polymorphonuclear Leukocyte) Function in Glycogenosis Type IB

Norman L Koven
Mimi M Clark
Steven D Douglas
Research01 May 1986
Pediatric Research

Volume: 20, P: 438-442
Maintenance of CD4 T cell fitness through regulation of Foxo1

Foxo proteins are required for maintaining T cell quiescence. Turka and colleagues use a constitutively active Foxo1 in T_reg cells to show that its downregulation is essential for maintaining their fitness in a competitive environment.

Ryan H. Newton
Sharad Shrestha
Laurence A. Turka
Research09 Jul 2018
Nature Immunology

Volume: 19, P: 838-848
Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19

SARS-CoV-2 infection can lead to progressive pathology in patients with COVID-19, but information for this disease progression is sparse. Here the authors use multi-omics approach to profile the immune responses of patients, assessing immune repertoire and effects of tocilizumab treatments, to find a dyssynchrony between innate and adaptive immunity in progressive COVID-19.

Avraham Unterman
Tomokazu S. Sumida
Charles S. Dela Cruz
ResearchOpen Access21 Jan 2022
Nature Communications

Volume: 13, P: 1-23
An in Vitro Study of Choline Uptake by Intestine from Neonatal and Adult Rats

Nancy F Sheard
Steven H Zeisel
Research01 Aug 1986
Pediatric Research

Volume: 20, P: 768-772
IL25 elicits a multipotent progenitor cell population that promotes T_H2 cytokine responses

Several non-haematopoietic-cell-derived cytokines, including interleukin (IL)25, have been implicated in inducing T helper 2 (T_H2) cell-dependent inflammation, but their precise role has been unclear. Here, IL25 is shown to promote the accumulation of multipotent progenitor cells in gut-associated lymphoid tissue. These cells can give rise to macrophage or granulocyte lineages that promote the differentiation of T_H2 cells and contribute to protective immunity against helminth infections.

Steven A. Saenz
Mark C. Siracusa
David Artis
Research01 Apr 2010
Nature

Volume: 464, P: 1362-1366
Intratumoral dendritic cell–CD4⁺ T helper cell niches enable CD8⁺ T cell differentiation following PD-1 blockade in hepatocellular carcinoma

Response to anti-PD-1 in patients with hepatocellular carcinoma is associated with clonal expansion of intratumoral CXCL13⁺ CD4⁺ helper T cells and effector-like CD8⁺ T cells, and local dendritic cells enriched in expression of maturation and regulatory molecules help facilitate CD8⁺ T cell differentiation.

Assaf Magen
Pauline Hamon
Miriam Merad
Research15 Jun 2023
Nature Medicine

Volume: 29, P: 1389-1399
Chromatin states define tumour-specific T cell dysfunction and reprogramming

Epigenetic programming of T cells in solid tumours from a functional to a dysfunctional state occurs in two phases, and only the first phase is reversible.

Mary Philip
Lauren Fairchild
Andrea Schietinger
Research17 May 2017
Nature

Volume: 545, P: 452-456
Re-examination of the relationship between marine virus and microbial cell abundances

Analysis of microbial cell and virus abundance estimates from 25 distinct marine surveys reveals that virus-to-microbial cell ratio decreases with microbial cell density, questioning the idea that viral abundance is always 10-fold higher.

Charles H. Wigington
Derek Sonderegger
Joshua S. Weitz
Research25 Jan 2016
Nature Microbiology

Volume: 1, P: 1-9
GABA_A receptor availability in clinical high-risk and first-episode psychosis: a [¹¹C]Ro15-4513 positron emission tomography study

Paulina B. Lukow
Julia J. Schubert
Gemma Modinos
ResearchOpen Access06 Sept 2025
Molecular Psychiatry

P: 1-10
Ly6c^Lo non-classical monocytes promote resolution of rhesus rotavirus-mediated perinatal hepatic inflammation

Anas Alkhani
Claire S. Levy
Amar Nijagal
ResearchOpen Access28 Apr 2020
Scientific Reports

Volume: 10, P: 1-13
Large-scale 3D printed fouling-resistant self-floating evaporator

This solar-driven interfacial desalination research integrates 3D printed modules modifications, decoupling design, anticorrosion treatment for high desalination efficiency and long-term stability. This self-floating setup utilizes natural cooling seawater to conduct thermal convection for downward freshwater collection.

Yiru Pu
Wenzhu Lin
Steven Wang
ResearchOpen Access17 Apr 2025
Nature Communications

Volume: 16, P: 1-10
Unexpected mutagen in fish

Wei Chen
John H. Weisburger
Stephen S. Hecht
Research13 Apr 1995
Nature

Volume: 374, P: 599
Dispersal of juveniles and variable recruitment in sessile marine species

Steven D. Gaines
Mark D. Bertness
Research10 Dec 1992
Nature

Volume: 360, P: 579-580
Incorporation of acetylcholinesterase into synaptic vesicles is associated with blockade of synaptic transmission

ALBERTO POLITOFF
ALAN L. BLITZ
STEVEN ROSE
Research24 Jul 1975
Nature

Volume: 256, P: 324-325
Restricted pollen flow of two woodland herbs determined by neutron-activation analysis

STEVEN N. HANDEL
Research01 Apr 1976
Nature

Volume: 260, P: 422-423
Structural similarity between TAFs and the heterotetrameric core of the histone octamer

Xiaoling Xie
Tetsuro Kokubo
Stephen K. Burley
Research28 Mar 1996
Nature

Volume: 380, P: 316-322
Differentiation of human embryonic stem cells to HOXA⁺ hemogenic vasculature that resembles the aorta-gonad-mesonephros

Human embryonic stem cells are differentiated to cells similar to the embryonic aorta-gonad-mesonephros, which gives rise to hematopoietic stem cells.

Elizabeth S Ng
Lisa Azzola
Andrew G Elefanty
Research17 Oct 2016
Nature Biotechnology

Volume: 34, P: 1168-1179
Crystal structure at 1.7 Å of the bovine papillomavirus-1 E2 DMA-binding domain bound to its DNA target

Rashmi S. Hegde
Steven R. Grossman
Paul B. Sigler
Research08 Oct 1992
Nature

Volume: 359, P: 505-512
Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2

Roan et al. use Olink and single‐cell RNA sequencing (scRNA-seq) to show a dysregulated crosstalk between the cellular and humoral immune responses in individuals with long COVID 8 months postinfection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Kailin Yin
Michael J. Peluso
Nadia R. Roan
ResearchOpen Access11 Jan 2024
Nature Immunology

Volume: 25, P: 218-225
Painful stimulation suppresses joint inflammation by inducing shedding of L-selectin from neutrophils

Holly J. Strausbaugh
Paul G. Green
Jon D. Levine
Research01 Sept 1999
Nature Medicine

Volume: 5, P: 1057-1061
Effects of Hypoxia on the Cellular Electrical Activity of Adult and Neonatal Canine Ventricular Myocardium

Steven M Yabek
Rinya Kato
Bramah N Singh
Research01 Dec 1985
Pediatric Research

Volume: 19, P: 1263-1267
Whole-brain annotation and multi-connectome cell typing of Drosophila

A consensus cell type atlas for the fly brain provides both an intellectual framework and open-source toolchains for brain-scale comparative connectomics.

Philipp Schlegel
Yijie Yin
Gregory S. X. E. Jefferis
ResearchOpen Access02 Oct 2024
Nature

Volume: 634, P: 139-152
Efficient integration of an intron RNA into double-stranded DNA by reverse splicing

Jian Yang
Steven Zimmerly
Alan M. Lambowitz
Research23 May 1996
Nature

Volume: 381, P: 332-335
A relationship between the yeast cell cycle genes CDC4 and CDC36 and the ets sequence of oncogenic virus E26

Thomas A. Peterson
John Yochem
Steven I. Reed
Research07 Jun 1984
Nature

Volume: 309, P: 556-558
A novel eye in 'eyeless' shrimp from hydrothermal vents of the Mid-Atlantic Ridge

Cindy Lee Van Dover
Ete Z. Szuts
J. R. Cann
Research02 Feb 1989
Nature

Volume: 337, P: 458-460
Detection of carcinogen–DNA adducts by radioimmunoassay

MIRIAM C. POIRIER
STUART H. YUSPA
STEVEN BLOBSTEIN
Research10 Nov 1977
Nature

Volume: 270, P: 186-188
Eccentricity forcing of Pliocene–Early Pleistocene climate revealed in a marine oxygen-isotope record

Steven C. Clemens
Ralf Tiedemann
Research27 Feb 1997
Nature

Volume: 385, P: 801-804
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Actin-containing matrix associated with the plasma membrane of murine tumour and lymphoid cells

Matthew F. Mescher
Mimi J. L. Jose
Steven P. Balk
Research15 Jan 1981
Nature

Volume: 289, P: 139-144
Tick extracellular vesicles enable arthropod feeding and promote distinct outcomes of bacterial infection

Extracellular vesicles have been implicated in the transmission of pathogens from the arthropod to the human host. Here the authors show that tick-derived extracellular vesicles play a role in feeding and modulate the outcome of bacterial infection.

Adela S. Oliva Chávez
Xiaowei Wang
Joao H. F. Pedra
ResearchOpen Access17 Jun 2021
Nature Communications

Volume: 12, P: 1-17

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