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Showing 1–6 of 6 results
Advanced filters: Author: Steven R. Gullans Clear advanced filters

  • Small interfering RNAs (siRNAs) can be systemically administered in non-human primates and significantly reduce expression from the mRNA against which they are directed. A therapeutic effect can also be achieved by targeting a microRNA (miRNA). A modified oligonucleotide directed against miR-122 was administered to monkeys, resulting in a reduction in serum cholesterol without detectable toxicity.

    • Joacim Elmén
    • Morten Lindow
    • Sakari Kauppinen
    Research
    Nature
    Volume: 452, P: 896-899

  • Microarray analysis greatly assists in defining functions of genes and elucidating important biological pathways. To enhance this power, a database or compendium of hundreds of gene-expression profiles was constructed using gene-deletion mutants of yeast. Statistical tools could then sift through the compendium to identify matching fingerprints of expression and thereby unearth, for example, therapeutic targets.

    • Steven R Gullans
    News & Views
    Nature Genetics
    Volume: 26, P: 4-5