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Showing 1–3 of 3 results
Advanced filters: Author: Steven Whitebread Clear advanced filters

  • In vitropharmacological profiling is playing an increasing part in identifying undesirable off-target effects of candidate drugs earlier in the drug discovery process. In this article, authors from four large pharmaceutical companies share their views on the rationale, strategies and methodologies forin vitropharmacological profiling, and recommend a minimal panel of targets for screening.

    • Joanne Bowes
    • Andrew J. Brown
    • Steven Whitebread
    Reviews
    Nature Reviews Drug Discovery
    Volume: 11, P: 909-922

  • A large-scale computational effort is used to predict the activity of 656 drugs against 73 protein targets that have been associated with adverse drug reactions; the abdominal pain side effect of the synthetic oestrogen chlorotrianisene is shown to be mediated through its inhibition of cyclooxygenase-1.

    • Eugen Lounkine
    • Michael J. Keiser
    • Laszlo Urban
    Research
    Nature
    Volume: 486, P: 361-367