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Showing 1–3 of 3 results
Advanced filters: Author: Stig Tollefsen Clear advanced filters

  • The association of particular major histocompatibility complex (MHC) polymorphisms with susceptibility to a number of autoimmune disease has been a puzzling phenomenon. This paper proposes a mechanism that might account in part for the onset of coeliac disease. Transaminase-mediated deamination of glutamine residues in gluten peptides may cause them to bind more tightly to disease-associated MHC alleles, activating heteroclitic gluten-peptide specific T-cell autoreactivity in the gut.

    • Zaruhi Hovhannisyan
    • Angela Weiss
    • Bana Jabri
    Research
    Nature
    Volume: 456, P: 534-538

  • On November 7th and 8th, 2022, The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), The Coalition for Epidemic Preparedness Innovation (CEPI), The Bill & Melinda Gates Foundation (BMGF), The Biomedical Advanced Research and Development Authority (BARDA), and the Wellcome Trust hosted a virtual workshop entitled “Mucosal Vaccines for SARS-CoV-2: Scientific Gaps and Opportunities.” During the workshop, researchers and vaccine developers from around the world discussed the potential of mucosal vaccines to block SARS-CoV-2 transmission and reviewed the status of SARS-CoV-2 mucosal vaccine research. Here, we summarize key challenges and opportunities in basic, translational, and clinical research that were highlighted during the meeting. We also provide recommendations to advance the field and accelerate the development of mucosal vaccines for SARS-CoV-2.

    • Jane M. Knisely
    • Lucas E. Buyon
    • Anthony S. Fauci
    News & ViewsOpen Access
    npj Vaccines
    Volume: 8, P: 1-7