SUV39H1 is a histone methyltransferase responsible for the repressive H3K9me3 mark. New data indicate that SUV39H1, via p21, is a target of p53 repression, leading to decreased H3K9me3 levels at p53 promoters and facilitating p53 activation of its target genes.
- Sathish Kumar Mungamuri
- Erica Kay Benson
- Stuart A Aaronson