Nature Search

ABO blood group antigens influence host–microbe interactions and risk of early spontaneous preterm birth

Katherine E. Mountain
David A. MacIntyre
Lynne Sykes
ResearchOpen Access10 Sept 2025
npj Biofilms and Microbiomes

Volume: 11, P: 1-13
Glyco-engineered MDCK cells display preferred receptors of H3N2 influenza absent in eggs used for vaccines

Evolution of human H3N2 influenza has limited the specificity of hemagglutinin to a subset of glycan receptors, which brings challenges. By glyco-engineering cell lines, authors show the importance of extended glycan receptors for growth of recent H3N2 viruses and relevance to their production for vaccines.

Chika Kikuchi
Aristotelis Antonopoulos
James C. Paulson
ResearchOpen Access04 Oct 2023
Nature Communications

Volume: 14, P: 1-13
Publisher Correction: Host and viral determinants of influenza A virus species specificity

Jason S. Long
Bhakti Mistry
Wendy S. Barclay
Amendments and Corrections18 Dec 2018
Nature Reviews Microbiology

Volume: 17, P: 124
Loss of GCNT2/I-branched glycans enhances melanoma growth and survival

Aberrant glycosylation patterns on cancer cells promote several pro-tumorigenic functions, including enhancing tumor cell proliferation. Here the authors provide data that show melanoma cells downregulate GCNT2 with consequent loss of I-branched glycans; this leads to the formation of extended i-linear glycans and enhances melanoma growth via increases, in part, by IGF-1- and extracellular matrix-induced signaling.

Jenna Geddes Sweeney
Jennifer Liang
Charles J. Dimitroff
ResearchOpen Access22 Aug 2018
Nature Communications

Volume: 9, P: 1-18
Immobilized enzyme cascade for targeted glycosylation

SUGAR-TARGET is a modular platform for the homogeneous synthesis of enzymes with controlled N-linked glycosylation using a one-step immobilization/purification method.

Elli Makrydaki
Roberto Donini
Cleo Kontoravdi
ResearchOpen Access06 Feb 2024
Nature Chemical Biology

Volume: 20, P: 732-741
Molecular mechanism of decision-making in glycosaminoglycan biosynthesis

Heparan sulfate (HS) and chondroitin sulfate (CS) are different glycosaminoglycan chains that are attached to core proteins via the same linker tetrasaccharide, and it was unclear how core proteins are specifically modified with HS or CS. Here, the authors determine that the CS-initiating glycosyltransferase CSGALNACT2 is promiscuous, whereas the HS-initiating glycosyltransferase EXTL3 selects only certain core proteins for modification.

Douglas Sammon
Anja Krueger
Erhard Hohenester
ResearchOpen Access13 Oct 2023
Nature Communications

Volume: 14, P: 1-13
Red blood cell mannoses as phagocytic ligands mediating both sickle cell anaemia and malaria resistance

Red blood cells (RBCs) are phagocytosed in the spleen in sickle cell disease and malaria. Here, Cao et al. show that high mannose N-glycans, exposed on diseased or oxidized RBC surfaces, bind mannose receptor CD206 on host cells, mediating phagocytosis.

Huan Cao
Aristotelis Antonopoulos
Mark A. Vickers
ResearchOpen Access19 Mar 2021
Nature Communications

Volume: 12, P: 1-13
Salivary Electrolytes in Infants Receiving Digoxin

Constance J Hayes
Stephen Wotman
Welton M Gersony
Research01 Apr 1974
Pediatric Research

Volume: 8, P: 363
Cell-specific bioorthogonal tagging of glycoproteins

Changes in glycoprotein expression are correlates of disease, but secreted glycoproteins cannot be accurately traced to their cell line of origin. Here, the authors develop a strategy to chemically tag and profile glycoproteins in a cell line-specific manner in co-culture systems and in vivo.

Anna Cioce
Beatriz Calle
Benjamin Schumann
ResearchOpen Access25 Oct 2022
Nature Communications

Volume: 13, P: 1-18
Loss of α2-6 sialylation promotes the transformation of synovial fibroblasts into a pro-inflammatory phenotype in arthritis

Dysregulation of synovial fibroblasts is thought to be an important step in the pathogenesis of rheumatoid arthritis. Here the authors implicate α2-6 sialylation in this process by studying the glycome of these cells in patients and in a mouse model of inflammatory joint disease.

Yilin Wang
Aneesah Khan
Miguel A. Pineda
ResearchOpen Access20 Apr 2021
Nature Communications

Volume: 12, P: 1-18
The highly conserved domain of unknown function 1792 has a distinct glycosyltransferase fold

Two glycosyltransferase folds have been reported, GT-A and GT-B. Here, Zhang et al.report a 1.34 Å resolution structure of a domain of unknown function that adopts a new glycosylation fold, and show that the protein functions as a glycosyltransferase.

Hua Zhang
Fan Zhu
Hui Wu
Research15 Jul 2014
Nature Communications

Volume: 5, P: 1-12
Cellular O-Glycome Reporter/Amplification to explore O-glycans of living cells

Addition of a glycan precursor to cells results in the synthesis and secretion of a large variety of O-glycans that can be purified and biochemically analyzed to profile the cellular O-glycome.

Matthew R Kudelka
Aristotelis Antonopoulos
Tongzhong Ju
Research30 Nov 2015
Nature Methods

Volume: 13, P: 81-86
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Openshaw and colleagues find myeloid inflammation and complement activation signatures in patients with long COVID who were previously hospitalized.

Felicity Liew
Claudia Efstathiou
J. Eunice Zhang
ResearchOpen Access08 Apr 2024
Nature Immunology

Volume: 25, P: 607-621
Author Correction: Community evaluation of glycoproteomics informatics solutions reveals high-performance search strategies for serum glycopeptide analysis

Rebeca Kawahara
Anastasia Chernykh
Morten Thaysen-Andersen
Amendments and CorrectionsOpen Access10 Dec 2021
Nature Methods

Volume: 19, P: 130
Global metabolic inhibitors of sialyl- and fucosyltransferases remodel the glycome

Fluorinated, cell-permeable analogs of sialic acid and fucose are processed by monosaccharide salvage pathways to generate sialyl- and fucosyltransferase inhibitors intracellularly. These compounds serve as important new tools to dissect the role of glycan modifications within complex biological systems.

Cory D Rillahan
Aristotelis Antonopoulos
James C Paulson
Research10 Jun 2012
Nature Chemical Biology

Volume: 8, P: 661-668
Community evaluation of glycoproteomics informatics solutions reveals high-performance search strategies for serum glycopeptide analysis

This analysis presents the results of a community-based evaluation of existing software for large-scale glycopeptide data analysis.

Rebeca Kawahara
Anastasia Chernykh
Morten Thaysen-Andersen
ResearchOpen Access01 Nov 2021
Nature Methods

Volume: 18, P: 1304-1316
Glycomics of cervicovaginal fluid from women at risk of preterm birth reveals immuno-regulatory epitopes that are hallmarks of cancer and viral glycosylation

Gang Wu
Paola Grassi
Stuart M. Haslam
ResearchOpen Access06 Sept 2024
Scientific Reports

Volume: 14, P: 1-18
JAGN1 deficiency causes aberrant myeloid cell homeostasis and congenital neutropenia

Christoph Klein and colleagues identify homozygous mutations in the JAGN1 gene in families and individuals with severe congenital neutropenia. They show that JAGN1 is necessary for the differentiation and survival of neutrophil granulocytes.

Kaan Boztug
Päivi M Järvinen
Christoph Klein
Research01 Sept 2014
Nature Genetics

Volume: 46, P: 1021-1027
N-glycosylation of cervicovaginal fluid reflects microbial community, immune activity, and pregnancy status

Gang Wu
Paola Grassi
Stuart M. Haslam
ResearchOpen Access10 Oct 2022
Scientific Reports

Volume: 12, P: 1-14
Host and viral determinants of influenza A virus species specificity

Influenza A viruses cause pandemics when they cross between species. In this Review, Barclay and colleagues examine the host barriers that influenza A viruses must overcome to initiate a pandemic in humans and describe how, on crossing the species barrier, the virus mutates to establish new interactions with the human host.

Jason S. Long
Bhakti Mistry
Wendy S. Barclay
Reviews28 Nov 2018
Nature Reviews Microbiology

Volume: 17, P: 67-81
Glycosylation of Trypanosoma cruzi TcI antigen reveals recognition by chagasic sera

Niamh Murphy
Barrie Rooney
Michael A. Miles
ResearchOpen Access02 Oct 2020
Scientific Reports

Volume: 10, P: 1-9
Proteome-wide prediction of bacterial carbohydrate-binding proteins as a tool for understanding commensal and pathogen colonisation of the vaginal microbiome

François Bonnardel
Stuart M. Haslam
Anne Imberty
ResearchOpen Access15 Jun 2021
npj Biofilms and Microbiomes

Volume: 7, P: 1-10
Developing the IVIG biomimetic, Hexa-Fc, for drug and vaccine applications

Daniel M. Czajkowsky
Jan Terje Andersen
Richard J. Pleass
ResearchOpen Access27 Apr 2015
Scientific Reports

Volume: 5, P: 1-11
Mapping the complete glycoproteome of virion-derived HIV-1 gp120 provides insights into broadly neutralizing antibody binding

Maria Panico
Laura Bouché
Howard R. Morris
ResearchOpen Access08 Sept 2016
Scientific Reports

Volume: 6, P: 1-17
Altered glycosylation of glycodelin in endometrial carcinoma

Glycodelin is a major endometrial glycoprotein. The authors analyzed glycan structures of endometrial carcinoma associated glycodelin and established a novel glycodelin-glycoform specific histochemical staining method. With this, they showed that glycodelin is differentially glycosylated in endometrial carcinoma tissue, as compared to normal endometrium, representing a neoantigen with potential clinical applications.

Laura C. Hautala
Poh-Choo Pang
Hannu Koistinen
ResearchOpen Access23 Mar 2020
Laboratory Investigation

Volume: 100, P: 1014-1025

Search

ABO blood group antigens influence host–microbe interactions and risk of early spontaneous preterm birth

Glyco-engineered MDCK cells display preferred receptors of H3N2 influenza absent in eggs used for vaccines

Publisher Correction: Host and viral determinants of influenza A virus species specificity

Loss of GCNT2/I-branched glycans enhances melanoma growth and survival

Immobilized enzyme cascade for targeted glycosylation

Molecular mechanism of decision-making in glycosaminoglycan biosynthesis

Red blood cell mannoses as phagocytic ligands mediating both sickle cell anaemia and malaria resistance

Salivary Electrolytes in Infants Receiving Digoxin

Cell-specific bioorthogonal tagging of glycoproteins

Loss of α2-6 sialylation promotes the transformation of synovial fibroblasts into a pro-inflammatory phenotype in arthritis

The highly conserved domain of unknown function 1792 has a distinct glycosyltransferase fold

Cellular O-Glycome Reporter/Amplification to explore O-glycans of living cells

Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Author Correction: Community evaluation of glycoproteomics informatics solutions reveals high-performance search strategies for serum glycopeptide analysis

Global metabolic inhibitors of sialyl- and fucosyltransferases remodel the glycome

Community evaluation of glycoproteomics informatics solutions reveals high-performance search strategies for serum glycopeptide analysis

Glycomics of cervicovaginal fluid from women at risk of preterm birth reveals immuno-regulatory epitopes that are hallmarks of cancer and viral glycosylation

JAGN1 deficiency causes aberrant myeloid cell homeostasis and congenital neutropenia

N-glycosylation of cervicovaginal fluid reflects microbial community, immune activity, and pregnancy status

Host and viral determinants of influenza A virus species specificity

Glycosylation of Trypanosoma cruzi TcI antigen reveals recognition by chagasic sera

Proteome-wide prediction of bacterial carbohydrate-binding proteins as a tool for understanding commensal and pathogen colonisation of the vaginal microbiome

Developing the IVIG biomimetic, Hexa-Fc, for drug and vaccine applications

Mapping the complete glycoproteome of virion-derived HIV-1 gp120 provides insights into broadly neutralizing antibody binding

Altered glycosylation of glycodelin in endometrial carcinoma

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