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Showing 1–4 of 4 results
Advanced filters: Author: Subbareddy Maddika Clear advanced filters

  • Rab7 is a critical GTPase for endosome maturation and it is implicated in the endocytic traffic of several receptors, including EGFR. In this study, the authors reveal the potential role of PTEN in the endocytic trafficking pathway of EGFR, which is dependent on its phosphatase activity through the direct post-translational modification of Rab7.

    • Swapnil Rohidas Shinde
    • Subbareddy Maddika
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-11

  • The kinase DYRK2 regulates the assembly of a ubiquitin ligase complex in a phosphorylation-independent manner, while also phosphorylating the target for the ligase. Thus, ligase assembly and target ubiquitylation appear to be physically linked processes.

    • Subbareddy Maddika
    • Junjie Chen
    Research
    Nature Cell Biology
    Volume: 11, P: 409-419

  • The stability of the PTEN tumour suppressor protein is regulated by polyubiquitylation. Ma and colleagues identify USP13 as an enzyme reversing polyubiquitylation of PTEN, leading to PTEN stabilization and tumour suppression.

    • Jinsong Zhang
    • Peijing Zhang
    • Li Ma
    Research
    Nature Cell Biology
    Volume: 15, P: 1486-1494

  • The lipid phosphatase and tumour suppressor PTEN is regulated by ubiquitylation. The E3 ligase WWP2/AIP-2 is found to mediate PTEN degradation and is suggested to function as an oncogene.

    • Subbareddy Maddika
    • Sridhar Kavela
    • Junjie Chen
    Research
    Nature Cell Biology
    Volume: 13, P: 728-733